ArticleDiabetes2014
Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance.
Article in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 94 citations in OpenAlex.
- Des-Aspartate Angiotensin-1: A Dual-Targeted Therapeutic for Perivascular Inflammation and Vascular Dysfunction in Obesity.Journal of cardiovascular translational research · 2025Review
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.Cardiovascular diabetology · 2024Article
- Association between the systemic immune-inflammation index and obesity among adults: Insights from the NHANES 2017-2018.PloS one · 2024Article
- Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet.Scientific reports · 2023Article
- Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys.World journal of pediatrics : WJP · 2023Article
- Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.Veterinary research communications · 2023Article
- Hypochlorous Acid Chemistry in Mammalian Cells-Influence on Infection and Role in Various Pathologies.International journal of molecular sciences · 2022Review
- Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- Neutrophils in chronic inflammatory diseases.Cellular & molecular immunology · 2022Review
- Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease.Journal of innate immunity · 2022Review
- Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs' Biochemical and Histopathological Abnormalities in an Animal Model.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Transcriptomics of circulating neutrophils in dairy cows with subclinical hypocalcemia.Frontiers in veterinary science · 2022Article
- COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors.Signal transduction and targeted therapy · 2021Article
- Characterization of inflammatory changes in the breast cancer associated adipose tissue and comparison to the unaffected contralateral breast.Surgical oncology · 2021Article
- Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration.Nature cancer · 2021Article
- Adipocytes, Innate Immunity and Obesity: A Mini-Review.Frontiers in immunology · 2021Review
- Class III obesity rather than metabolic syndrome impacts clinical outcomes of acute pancreatitis: A propensity score weighted analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Article
- Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions.Clinical reviews in allergy & immunology · 2020Review
- Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity.Circulation research · 2020Review
Corrections and comments
- Retraction · 2021-06-28Falsification/Fabrication of Image · Investigation by Company/Institution ·
- Commented on by
- Retracted
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Activation of myeloperoxidase (MPO), a heme protein primarily expressed in granules of neutrophils, is associated with the development of obesity. However, whether MPO mediates high-fat diet (HFD)-induced obesity and obesity-associated insulin resistance remains to be determined. Here, we found that consumption of an HFD resulted in neutrophil infiltration and enhanced MPO expression and activity in epididymal white adipose tissue, with an increase in body weight gain and impaired insulin signaling. MPO knockout (MPO(-/-)) mice were protected from HFD-enhanced body weight gain and insulin resistance. The MPO inhibitor 4-aminobenzoic acid hydrazide reduced peroxidase activity of neutrophils and prevented HFD-enhanced insulin resistance. MPO deficiency caused high body temperature via upregulation of uncoupling protein-1 and mitochondrial oxygen consumption in brown adipose tissue. Lack of MPO also attenuated HFD-induced macrophage infiltration and expression of proinflammatory cytokines. We conclude that activation of MPO in adipose tissue contributes to the development of obesity and obesity-associated insulin resistance. Inhibition of MPO may be a potential strategy for prevention and treatment of obesity and insulin resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.