ArticleScientific reports2014
Modelling lipid competition dynamics in heterogeneous protocell populations.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Stochastic Model for the Internal Transfer Kinetics of Cargo in Carriers with Two Compartments.Membranes · 2025Article
- Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Dynamical interactions among protocell populations: Implications for membrane-mediated chemical evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Light energy transduction in liposome-based artificial cells.Frontiers in bioengineering and biotechnology · 2023Review
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Prebiological Membranes and Their Role in the Emergence of Early Cellular Life.The Journal of membrane biology · 2020Review
- Dynamics of the vesicles composed of fatty acids and other amphiphile mixtures: unveiling the role of fatty acids as a model protocell membrane.Biophysical reviews · 2020Article
- The Construction of Biological 'Inter-Identity' as the Outcome of a Complex Process of Protocell Development in Prebiotic Evolution.Frontiers in physiology · 2020Article
- Replication of Simulated Prebiotic Amphiphilic Vesicles in a Finite Environment Exhibits Complex Behavior That Includes High Progeny Variability and Competition.Astrobiology · 2018Article
- Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research.Beilstein journal of organic chemistry · 2017Article
- Synthetic transitions: towards a new synthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Emergent chemical behavior in variable-volume protocells.Life (Basel, Switzerland) · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to 'steal' lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into competition amongst the vesicles. Such a scenario is interesting from an origins of life perspective because a rudimentary form of cell-level selection emerges. To sharpen intuition about possible mechanisms underlying this behaviour, experimental work must be complemented with theoretical modelling. The aim of this paper is to provide a coarse-grain mathematical model of protocell lipid competition. Our model is capable of reproducing, often quantitatively, results from core experimental papers that reported distinct types vesicle competition. Additionally, we make some predictions untested in the lab, and develop a general numerical method for quickly solving the equilibrium point of a model vesicle population.
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