ArticleBrain structure & function2015
Working memory training impacts the mean diffusivity in the dopaminergic system.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression.Translational psychiatry · 2023Trial
- Adaptive working memory training does not produce transfer effects in cognition and neuroimaging.Translational psychiatry · 2022Trial
- Dopamine and Acetylcholine in the Striatum: Circuit Interactions and Behavioral Control in Substance Use Disorders.Brain sciences · 2026Review
- A Diffusion Tensor Imaging Study on the White Matter Structures Related to the Phonology in Cantonese-Mandarin Bilinguals.Frontiers in human neuroscience · 2022Article
- Childhood socioeconomic status is associated with psychometric intelligence and microstructural brain development.Communications biology · 2021Article
- The Neurocognitive Effects ofFrontiers in aging neuroscience · 2021Article
- Article
- The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity.Scientific reports · 2020Article
- Mean diffusivity associated with trait emotional intelligence.Social cognitive and affective neuroscience · 2019Article
- Empathizing associates with mean diffusivity.Scientific reports · 2019Article
- Shorter sleep duration and better sleep quality are associated with greater tissue density in the brain.Scientific reports · 2018Article
- The Effects of Family Socioeconomic Status on Psychological and Neural Mechanisms as Well as Their Sex Differences.Frontiers in human neuroscience · 2018Article
- Mean Diffusivity in the Dopaminergic System and Neural Differences Related to Dopaminergic System.Current neuropharmacology · 2018Review
- Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training.Scientific reports · 2017Article
- Impact of videogame play on the brain's microstructural properties: cross-sectional and longitudinal analyses.Molecular psychiatry · 2016Article
- Working memory training improves emotional states of healthy individuals.Frontiers in systems neuroscience · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components.
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