Evidence map›Paper›PMID 25023716›Full record

ArticleArchives of women's mental health2014

Characteristics and quality of life of opioid-dependent pregnant women in Austria.

Verena E Metz, Sandra D Comer, Johanna Wuerzl, Anna Pribasnig, Gabriele Fischer

Open access · greenAbstract read
In one paragraph

Article in Archives of women's mental health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Intact responses to non-drug rewards in long-term opioid maintenance treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Pooled it
  2. Article
  3. Determinants of Quality of Life in High-Dose Benzodiazepine Misusers.International journal of environmental research and public health · 2017
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Verena E MetzDepartment of Psychiatry, Columbia University and NYSPI, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA, metzver@nyspi.columbia.edu.
Sandra D Comer
Johanna Wuerzl
Anna Pribasnig
Gabriele Fischer
Medical University of Vienna · ATColumbia University · US

Funding

PHARMACOLOGICAL TREATMENT OF MARIJUANA DEPENDENCEP50DA009236 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KLEBER, HERBERT DAVID · 1994 to 2013
$39.4M
Maternal Opioid Treatment: Human ExperimentalR01DA018417 · NIDA · MEDICAL UNIVERSITY OF VIENNA · PI FISCHER, GABRIELE · 2004 to 2008
$1.8M
NIDA NIH HHS DA09236NIDA NIH HHS P50 DA009236NIDA NIH HHS R01 DA018417NIDA NIH HHS R01DA018417
6 · The paper itself

Abstract

This study investigated pregnant opioid-dependent women undergoing maintenance therapy, applying a multidisciplinary, case-management approach at the Addiction Clinic of the Medical University of Vienna, Austria. It aimed at characterizing the patients' basic demographic and clinical parameters and evaluating their overall quality of life (QoL) prepartum and postpartum. Three hundred ninety women were treated between 1994 and 2009 with buprenorphine (n = 77), methadone (n = 184), or slow-release oral morphine (SROM) (n = 129) on an outpatient basis throughout their pregnancy and postpartum period. All patients were subject to standardized prepartum and postpartum medical and psychiatric assessments, including QoL assessments using a German adaptation of the Lancashire QoL Profile (Berliner Lebensqualitaetsprofil), and regular supervised urine toxicologies. No medication group differences were revealed regarding basic demographic or clinical data. Mean maintenance doses (SD) at time of delivery were as follows: 64 mg (36 mg) methadone, 10 mg (6 mg) buprenorphine, 455 mg (207 mg) SROM. However, buprenorphine-medicated women showed significantly less concomitant benzodiazepine consumption than methadone- or SROM-maintained women (p = 0.005), and significantly less concomitant opioid consumption than methadone-maintained women (p = 0.033) during the last trimester. Overall QoL was good prepartum and postpartum in all measured domains except "finances" and "prospect of staying in the same housing situation," and no differences were observed in QoL among the three medication groups (p = 0.177). QoL improved significantly after delivery in most of the domains (p < 0.001). Although opioid-dependent pregnant women face high-risk pregnancies and show variability in addiction severity, they report good QoL independent of the medication administered. These results show that individually tailored treatment interventions are effective for this patient population and suggest a QoL improvement after delivery.

Indexed as

Administration, OralAdultAustriaBuprenorphineDelayed-Action PreparationsFemaleHumansMethadoneMorphineNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersPregnancyPregnancy OutcomePregnancy Trimester, ThirdPregnant PeopleBuprenorphineDelayed-Action PreparationsMethadoneMorphineNarcotics

Identifiers

PMID25023716
PMCPMC4239179
OpenAlexW2033167633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.