ReviewThe International journal of developmental biology2014
BMP4 regulation of human trophoblast development.
Review in The International journal of developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Lineage-Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Induction of human trophoblast stem-like cells from primed pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- From Mice to Men: Generation of Human Blastocyst-Like StructuresFrontiers in cell and developmental biology · 2022Review
- NLRP7: From inflammasome regulation to human disease.Immunology · 2021Review
- LncRNAInternational journal of molecular sciences · 2021Article
- Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation.Nature communications · 2020Article
- Article
- Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.Stem cell reports · 2018Article
- Human trophoblast stem cell self-renewal and differentiation: Role of decorin.Scientific reports · 2018Article
- Trophoblast lineage specification, differentiation and their regulation by oxygen tension.The Journal of endocrinology · 2018Review
- Human trophoblast stem cells: Real or not real?Placenta · 2017Review
- The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states.BMC developmental biology · 2017Review
- ARID3A is required for mammalian placenta development.Developmental biology · 2017Article
- Notch1 controls development of the extravillous trophoblast lineage in the human placenta.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Tipping the balance toward trophoblast development.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua.Placenta · 2015Article
- Signaling pathways in mouse and human trophoblast differentiation: a comparative review.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Since the derivation of human embryonic stem cells, and the subsequent generation of induced pluripotent stem cells, there has been much excitement about the ability to model and evaluate human organ development in vitro. The finding that these cells, when treated with BMP4, are able to generate the extraembryonic cell type, trophoblast, which is the predominant functional epithelium in the placenta, has not been widely accepted. This review evaluates this model, providing comparison to early known events during placentation in both human and mouse and addresses specific challenges. Keeping in mind the ultimate goal of understanding human placental development and pregnancy disorders, our aim here is two-fold: to distinguish gaps in our knowledge arising from mis- or over-interpretation of data, and to recognize the limitations of both mouse and human models, but to work within those limitations towards the ultimate goal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.