ArticleJournal of hypertension2014
Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood.
Article in Journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Circulating levels of 25-hydroxyvitamin D in relation to hypertension in children and adolescents: a systematic review and dose-response meta-analysis of epidemiologic studies with GRADE assessment.Journal of translational medicine · 2025Pooled it
- A Health-Literacy Intervention for Early Childhood Obesity Prevention: A Cluster-Randomized Controlled Trial.Pediatrics · 2021Trial
- Prevalence of high blood pressure subtypes and its associations with BMI in Chinese children: a national cross-sectional survey.BMC public health · 2017Trial
- Bottle Size and Weight Gain in Formula-Fed Infants.Pediatrics · 2016Trial
- Dietary and activity habits associated with hypertension in Kunming school-aged children and adolescents: A multilevel analysis of the study of hypertension risks in children and adolescents.Preventive medicine reports · 2024Article
- The association of intrauterine and postnatal growth patterns and nutritional status with toddler body composition.BMC pediatrics · 2023Article
- Neonatal Leptin Levels Predict the Early Childhood Developmental Assessment Scores of Preterm Infants.Nutrients · 2023Article
- Childhood BMI and other measures of body composition as a predictor of cardiometabolic non-communicable diseases in adulthood: a systematic review.Public health nutrition · 2023Review
- Neonatal hypertension: concerns within and beyond the neonatal intensive care unit.Clinical and experimental pediatrics · 2022Article
- Prevalence and incidence of pre-hypertension and hypertension (awareness/control) in Iran: findings from Kerman coronary artery diseases risk factors study 2 (KERCADRS).Journal of human hypertension · 2022Article
- Prevalence trends of hypertension and influence factors among children and adolescents aged 7-17 years in China, 2011-2015: A serial cross-sectional study.Frontiers in public health · 2022Article
- Prevalence trends of hypertension among 9-17 aged children and adolescents in Yunnan, 2017-2019: a serial cross-sectional surveillance survey.BMC public health · 2021Article
- Low Birthweight Is Associated with Higher Risk of High Blood Pressure in Chinese Girls: Results from a National Cross-Sectional Study in China.International journal of environmental research and public health · 2019Article
- National trends of pre-hypertension and hypertension among Iranian adolescents across urban and rural areas (2007-2011).Biology of sex differences · 2019Article
- Infant Growth and Long-term Cardiometabolic Health: a Review of Recent Findings.Current nutrition reports · 2019Review
- Interpregnancy interval, maternal age, and offspring's BMI and blood pressure at 7 years of age.Journal of human hypertension · 2018Article
- Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.BMJ open · 2018Article
- Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice.Frontiers in immunology · 2018Article
- Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain.Scientific reports · 2017Article
- Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence.Journal of the American Heart Association · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSmall size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known.
methodsUsing data from 3154 people from the Avon Longitudinal Study of Parents and Children, we assessed associations between repeated measures of BMI from birth to age 10 with central and brachial BP at age 17.
resultsLower BMI at birth (thinness) was associated with greater central and brachial BP. No associations were seen between BMI in early childhood (<7 years) and later BP, but greater BMI from 7 to 10 years was associated with higher BP. Associations were similar for central and brachial SBP and for DBP, and were stronger in males compared with females. The highest BP was seen in participants who were low-birth-weight and overweight or obese at both the end of infancy (age 2) and at the time of BP assessment (age 17); mean central SBP was 104.2 mmHg (SD = 11.0) compared with 100.7 (SD = 10.5) in participants who were normal-birth-weight and overweight or obese at 2 and 17 years.
conclusionSmall size at birth followed by rapid adiposity gain in infancy and continued overweight/obesity are associated with greater BP in young adulthood. These findings emphasize the importance of maintenance of normal weight in childhood for the prevention of high BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.