Evidence map›Paper›PMID 25023143›Full record

ArticleMolecular psychiatry2015

The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort.

E B Robinson, A Kirby, K Ruparel, J Yang, L McGrath, V Anttila, B M Neale, K Merikangas, T Lehner, P M A Sleiman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  16. Sociogenomics in the 21Sociology compass · 2018
    Article
  17. COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

E B Robinson1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
A Kirby1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
K RuparelDepartment of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J YangQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
L McGrathPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
V Anttila1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA [3] Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
B M Neale1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
K MerikangasGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
T LehnerOffice of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
P M A SleimanCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
M J Daly1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
R GurDepartment of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R GurDepartment of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
H HakonarsonCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M
2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
Neurodevelopmental Genomics SupplementZIAMH002931 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2011 to 2015
$1.2M
The genomic bridge project (GBP)K01MH099286 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROBINSON, ELISE B · 2013 to 2016
$647k
NICHD NIH HHS U54 HD086984NIMH NIH HHS 1K01MH099286-01A1NIMH NIH HHS K01 MH099286NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983
6 · The paper itself

Abstract

The objective of this analysis was to examine the genetic architecture of diverse cognitive abilities in children and adolescents, including the magnitude of common genetic effects and patterns of shared and unique genetic influences. Subjects included 3689 members of the Philadelphia Neurodevelopmental Cohort, a general population sample comprising those aged 8-21 years who completed an extensive battery of cognitive tests. We used genome-wide complex trait analysis to estimate the SNP-based heritability of each domain, as well as the genetic correlation between all domains that showed significant genetic influence. Several of the individual domains suggested strong influence of common genetic variants (for example, reading ability, h(2)g=0.43, P=4e-06; emotion identification, h(2)g=0.36, P=1e-05; verbal memory, h(2)g=0.24, P=0.005). The genetic correlations highlighted trait domains that are candidates for joint interrogation in future genetic studies (for example, language reasoning and spatial reasoning, r(g)=0.72, P=0.007). These results can be used to structure future genetic and neuropsychiatric investigations of diverse cognitive abilities.

Indexed as

AdolescentChildCognition DisordersCohort StudiesCommunity Health PlanningDevelopmental DisabilitiesFemaleGenetic Predisposition to DiseaseGenomicsGenotypeHumansMaleNeuropsychological TestsPediatricsPhenotypePhiladelphia

Identifiers

PMID25023143
PMCPMC4294962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.