Evidence map›Paper›PMID 25023134›Full record

SynthesisTranslational stroke research2015

The effects of poststroke aerobic exercise on neuroplasticity: a systematic review of animal and clinical studies.

Michelle Ploughman, Mark W Austin, Lindsay Glynn, Dale Corbett

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Translational stroke research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 9 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 9 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  8. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2016
    Pooled it
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  10. Energy Cost of Walking in Relation to Impairment and Functional Independence After Stroke: The Role of Walking Speed.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Michelle PloughmanRecovery and Performance Laboratory, Rehabilitation Research Unit, Faculty of Medicine, Memorial University, Rm 400, L.A. Miller Centre, 100 Forest Rd., St. John's, NL, Canada, michelle.ploughman@med.mun.ca.
Mark W Austin
Lindsay Glynn
Dale Corbett
St. John's University · USHeart and Stroke Foundation · CAMemorial University of Newfoundland · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise may be a catalyst to promote neuroplasticity and recovery following stroke; however, the optimal methods to measure neuroplasticity and the effects of training parameters have not been fully elucidated. We conducted a systematic review and synthesis of clinical trials and studies in animal models to determine (1) the extent to which aerobic exercise influences poststroke markers of neuroplasticity, (2) the optimal parameters of exercise required to induce beneficial effects, and (3) consistent outcomes in animal models that could help inform the design of future trials. Synthesized findings show that forced exercise at moderate to high intensity increases brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I), nerve growth factor (NGF), and synaptogenesis in multiple brain regions. Dendritic branching was most responsive to moderate rather than intense training. Disparity between clinical stroke and stroke models (timing of initiation of exercise, age, gender) and clinically viable methods to measure neuroplasticity are some of the areas that should be addressed in future research.

Indexed as

Exercise TherapyNeuronal PlasticityStroke RehabilitationAgedAnimalsBrainBrain-Derived Neurotrophic FactorClinical Trials as TopicDendritesFemaleHumansInsulin-Like Growth Factor IMaleMiddle AgedNerve Growth FactorRecovery of FunctionBrain-Derived Neurotrophic FactorInsulin-Like Growth Factor INerve Growth Factor

Identifiers

PMID25023134
OpenAlexW2078355922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.