ArticleBMJ open2014
Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Perinatal stress and methylation of theEpigenetics · 2022Pooled it
- Early Life Stress, DNA Methylation of NR3C1 and HSD11B2 , and Oral Feeding Skill Development in Preterm Infants : A Pilot Study.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2025Article
- Extrauterine support of pre-term lambs achieves similar transcriptomic profiling to late pre-term lamb brains.Scientific reports · 2024Article
- Collaborating to Improve Neonatal Care: ParentAl Participation on the NEonatal Ward-Study Protocol of the neoPARTNER Study.Children (Basel, Switzerland) · 2023Article
- Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR.Cell death & disease · 2023Article
- Multi-level hypothalamic neuromodulation of self-regulation and cognition in preterm infants: Towards a control systems model.Comprehensive psychoneuroendocrinology · 2022Review
- Resilience to stress and social touch.Current opinion in behavioral sciences · 2022Review
- AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level.Heliyon · 2020Article
- DNA methylation biomarkers of future health outcomes in children.Molecular and cellular pediatrics · 2020Review
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability.Frontiers in psychiatry · 2020Review
- [Research advances in the effect of environmental stress in the neonatal intensive care unit on the neurodevelopment of preterm infants and its epigenetics].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Looking back and moving forward: Evaluating and advancing translation from animal models to human studies of early life stress and DNA methylation.Developmental psychobiology · 2019Article
- The biological embedding of neonatal stress exposure: A conceptual model describing the mechanisms of stress-induced neurodevelopmental impairment in preterm infants.Research in nursing & health · 2019Article
- Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood.BMC medical genomics · 2019Article
- Preterm Birth and the Risk of Neurodevelopmental Disorders - Is There a Role for Epigenetic Dysregulation?Current genomics · 2018Review
- Postnatal relative adrenal insufficiency results in methylation of the glucocorticoid receptor gene in preterm infants: a retrospective cohort study.Clinical epigenetics · 2018Article
- Telomere Length in Preterm Infants: A Promising Biomarker of Early Adversity and Care in the Neonatal Intensive Care Unit?Frontiers in endocrinology · 2017Article
- Medical morbidities and DNA methylation of NR3C1 in preterm infants.Pediatric research · 2017Article
- Early Caregiving and Human Biobehavioral Development: A Comparative Physiology Approach.Current opinion in behavioral sciences · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the environmental effects on cytosine methylation of preterm infant's DNA, because early life experiences are considered to influence the physiological and mental health of an individual through epigenetic modification of DNA.
designA prospective cohort study, comparison of epigenetic differences in the glucocorticoid receptor (GR) gene between healthy term and preterm infants.
settingNeonatal Intensive Care Unit in a Japanese University Hospital.
participantsA cohort of 40 (20 term and 20 preterm) infants was recruited on the day of birth, and peripheral blood was obtained from each infant at birth and on postnatal day 4.
main outcome measuresThe methylation rates in the 1-F promoter region of the GR gene using the Mquant method.
resultsThe methylation rate increased significantly between postnatal days 0 and 4 in preterm infants but remained stable in term infants. Thus, the methylation rate was significantly higher in preterm than in term infants at postnatal day 4. Several perinatal parameters were significantly correlated with this change in the methylation rate. Logistic regression analysis revealed that methylation rates at postnatal day 4 predicted the occurrence of later complications that required glucocorticoid administration during the neonatal period. No gene polymorphism was detected within the GR promoter region analysed.
conclusionsAlthough further large-scale studies are needed to detect the environmental factors that explain the difference in epigenetic modification among infants after birth, our data show that the postnatal environment influences epigenetic programming of GR expression through methylation of the GR gene promoter in premature infants, which may result in relative glucocorticoid insufficiency during the postnatal period.
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