ArticleScientific reports2014
Synergistic delivery of gold nanorods using multifunctional microbubbles for enhanced plasmonic photothermal therapy.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Recent advances in ultrasound microbubble-mediated gold-based nanomaterials for cancer theranostics.Frontiers in chemistry · 2026Review
- Evaluating ECM stiffness and liver cancer radiation response via shear-wave elasticity in 3D culture models.Radiation oncology (London, England) · 2024Article
- Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.Pharmaceutics · 2023Review
- Microbubbles Stabilized by Protein Shell: From Pioneering Ultrasound Contrast Agents to Advanced Theranostic Systems.Pharmaceutics · 2022Review
- Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor.Bioactive materials · 2022Article
- Sonazoid-Conjugated Natural Killer Cells for Tumor Therapy and Real-Time Visualization by Ultrasound Imaging.Pharmaceutics · 2021Article
- A Critical Review for Synergic Kinetics and Strategies for Enhanced Photopolymerizations for 3D-Printing and Additive Manufacturing.Polymers · 2021Review
- Environmental risk of nanomaterials and nanoparticles and EPR technique as an effective tool to study them-a review.Environmental science and pollution research international · 2021Review
- Optoacoustic/Fluorescent/Acoustic Imaging Probe Based on Air-Filled Bubbles Functionalized with Gold Nanorods and Fluorescein Isothiocyanate.ACS omega · 2021Article
- Air-Filled Bubbles Stabilized by Gold Nanoparticle/Photodynamic Dye Hybrid Structures for Theranostics.Nanomaterials (Basel, Switzerland) · 2021Article
- Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation.International journal of molecular sciences · 2020Article
- Photoacoustic imaging of cells in a three-dimensional microenvironment.Journal of biomedical science · 2020Review
- Magnetic-Plasmonic Heterodimer Nanoparticles: Designing Contemporarily Features for Emerging Biomedical Diagnosis and Treatments.Nanomaterials (Basel, Switzerland) · 2019Review
- Photoacoustic-Based Multimodal Nanoprobes: from Constructing to Biological Applications.International journal of biological sciences · 2017Review
- Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.Nature materials · 2016Article
- Nanodroplet-Vaporization-Assisted Sonoporation for Highly Effective Delivery of Photothermal Treatment.Scientific reports · 2016Article
- Multifunctional Inorganic Nanoparticles: Recent Progress in Thermal Therapy and Imaging.Nanomaterials (Basel, Switzerland) · 2016Review
- Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmonic photothermal therapy (PPTT) using plasmonic nanoparticles as efficient photoabsorbing agents has been proposed previously. One critical step in PPTT is to effectively deliver gold nanoparticles into the cells. This study demonstrates that the delivery of gold nanorods (AuNRs) can be greatly enhanced by combining the following three mechanisms: AuNRs encapsulated in protein-shell microbubbles (AuMBs), molecular targeting, and sonoporation employing acoustic cavitation of microbubbles (MBs). Both in vitro and in vivo tests were performed. For molecular targeting, the AuMBs were modified with anti-VEGFR2. Once bound to the angiogenesis markers, the MBs were destroyed by ultrasound to release the AuNRs and the release was confirmed by photoacoustic measurements. Additionally, acoustic cavitation was induced during MB destruction for sonoporation (i.e., increase in transient cellular permeability). The measured inertial cavitation dose was positively correlated with the temperature increase at the tumor site. The quantity of AuNRs delivered into the cells was also determined by measuring the mass spectrometry and observed using third-harmonic-generation microscopy and two-photon fluorescence microscopy. A temperature increase of 20 °C was achieved in vitro. The PPTT results in vivo also demonstrated that the temperature increase (>45 °C) provided a sufficiently high degree of hyperthermia. Therefore, synergistic delivery of AuNRs was demonstrated.
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