ArticleBMC complementary and alternative medicine2014
Antibacterial activities of Beilschmiedia obscura and six other Cameroonian medicinal plants against multi-drug resistant Gram-negative phenotypes.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Beilschmiedia species: from chemistry to pharmacological values.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Cytotoxic Lignan and Flavonoid Derivatives from the Branches ofJournal of natural products · 2025Article
- Effectiveness of African herbal preparations against multidrug-resistantScientific African · 2025Article
- Evaluating phytochemical constituents andHeliyon · 2023Article
- Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection.Health science reports · 2022Article
- Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes.BMC complementary medicine and therapies · 2022Article
- Cytotoxicity, acute and sub-chronic toxicities of the fruit extract of Tetrapleura tetraptera (Schumm. & Thonn.) Taub. (Fabaceae).BMC complementary medicine and therapies · 2022Article
- A New Chalcone and Antimicrobial Chemical Constituents ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Effect ofMetabolism open · 2022Article
- Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant ofMolecules (Basel, Switzerland) · 2021Article
- An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals fromTheScientificWorldJournal · 2021Article
- Antibacterial efficacy ofVeterinary world · 2019Article
- Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds fromEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Review on medicinal plants and natural compounds as anti-Onchocerca agents.Parasitology research · 2018Review
- Antibacterial activities of the methanol extracts ofSaudi journal of biological sciences · 2017Article
- Antibacterial activities of the methanol extracts of Canarium schweinfurthii and four other Cameroonian dietary plants against multi-drug resistant Gram-negative bacteria.Saudi journal of biological sciences · 2016Article
- Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes.BMC complementary and alternative medicine · 2016Article
- In vitro antibacterial activity of selected medicinal plants traditionally used in Vietnam against human pathogenic bacteria.BMC complementary and alternative medicine · 2016Article
- Antibacterial and antibiotic-modifying activities of three food plants (Xanthosoma mafaffa Lam., Moringa oleifera (L.) Schott and Passiflora edulis Sims) against multidrug-resistant (MDR) Gram-negative bacteria.BMC complementary and alternative medicine · 2016Article
- Cytotoxicity of methanol extracts ofSpringerPlus · 2016Article
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3 authors.
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Abstract
backgroundThe rapid spread of bacteria expressing multi-drug resistance propels the search for new antibacterial agents. The present study was designed to evaluate the antibacterial activities of the methanol extracts from Beilschmiedia obscura and six other Cameroonian plants against a panel of twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes.
methodsThe phytochemical investigations of the extracts were carried out according to the standard methods and the liquid micro-dilution assay was used for all antibacterial assays.
resultsPhytochemical analysis showed the presence of alkaloids in all studied extracts. Other chemical classes of secondary metabolites such as anthocyanines, anthraquinones flavonoids, saponins, tannins, sterols and triterpenes were selectively detected in the extracts. The extract from the fruits of Beilschmiedia obscura, Pachypodanthium staudtii leaves and Peperomia fernandopoiana (whole plant) displayed the best spectrum of activity with MIC values ranging from 16 to 1024 μg/mL against at least 65% and above of the tested bacteria. The extract from Beilschmiedia obscura was the most active with MIC values below 100 μg/mL against ten of the tested bacteria. This extract also showed MBC values below 1024 μg/mL against 55.17% of the studied microorganisms. Phenylalanine arginine β-naphthylamide (PAβN) significantly modulated the activities of extracts from the leaves and fruits of Pachypodanthium staudtii and Beilschmiedia obscura respectively, by increasing their inhibitory activity against Klebsiella pneumoniae KP55 strain at least four fold.
conclusionThe overall results of the present investigation provide information for the possible use of the methanol extracts of the studied plant species, especially B. obscura to fight infectious diseases caused by Gram-negative bacteria including MDR phenotypes.
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