Evidence map›Paper›PMID 25022852›Full record

ArticleJournal of bacteriology2014

Emerging roles for anionic non-bilayer phospholipids in fortifying the outer membrane permeability barrier.

Russell E Bishop

Abstract readComment
In one paragraph

Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
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  6. Article
  7. Presence of substrate aids lateral gate separation in LptD.Biochimica et biophysica acta. Biomembranes · 2020
    Article
  8. TheeLife · 2019
    Article
  9. Article
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  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Russell E BishopDepartment of Biochemistry and Biomedical Sciences, and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada bishopr@mcmaster.ca.

Funding

Canadian Institutes of Health Research MOP-125979
6 · The paper itself

Abstract

Lately, researchers have been actively investigating Escherichia coli lptD mutants, which exhibit reduced transport of lipopolysaccharide to the cell surface. In this issue of the Journal of Bacteriology, Sutterlin et al. (H. A. Sutterlin, S. Zhang, and T. J. Silhavy, J. Bacteriol. 196:3214-3220, 2014) now reveal an important functional role for phosphatidic acid in fortifying the outer membrane permeability barrier in certain lptD mutant backgrounds. These findings come on the heels of the first reports of two LptD crystal structures, which now provide a structural framework for interpreting lptD genetics.

Indexed as

Vancomycin ResistanceBacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsNucleotidyltransferasesPhosphatidic AcidsBacterial Outer Membrane ProteinsEscherichia coli ProteinsLptD protein, E coliNucleotidyltransferasesphosphatidate cytidylyltransferasePhosphatidic Acids

Identifiers

PMID25022852
PMCPMC4135697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.