ArticlePediatrics2014
Obstructive sleep apnea and sickle cell anemia.
Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- The bidirectional association between obstructive sleep apnea and diabetic kidney disease: systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease.Blood advances · 2019Guideline
- Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019Guideline
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- The Natural History of Snoring in Children With Sickle Cell Anemia in Relation to Upper Airway Anatomy and OSA.Pediatric pulmonology · 2026Article
- Airborne injustice: a preliminary exploration of the associations between pollutants and hospitalizations, sleep, and cognition in children and young adults living with sickle cell disease.Journal of pediatric psychology · 2025Article
- Hydroxyurea Therapy and Sleep-Disordered Breathing in Children With Sickle Cell Disease.Pediatric blood & cancer · 2025Article
- Multicenter comparative study of polysomnography outcomes in children with the monogenic disorder sickle cell disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Ambulatory pediatric adenotonsillectomy.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Review
- Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2024Review
- Role of endothelial dysfunction in sleep-disordered breathing in egyptian children with sickle cell disease.BMC pediatrics · 2024Article
- SNAP: Supportive non-invasive ventilation for acute chest syndrome prevention for hospitalized children with sickle cell disease: Perspectives of patients, parents, and the healthcare team.Pediatric blood & cancer · 2024Article
- Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.Blood advances · 2023Article
- Sleep and fatigue among youth with sickle cell disease: A daily diary study.Journal of behavioral medicine · 2023Article
- Outcomes before and after providing interdisciplinary hematology and pulmonary care for children with sickle cell disease.Blood advances · 2023Article
- Sleep disordered breathing and its relation to stroke and pulmonary hypertension in children with sickle cell disease: a single-center cross-sectional study.Annals of hematology · 2023Article
- Mind the gap: trajectory of cognitive development in young individuals with sickle cell disease: a cross-sectional study.Frontiers in neurology · 2023Article
- The Cardiopulmonary Complications of Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveTo ascertain the prevalence of and risk factors for obstructive sleep apnea syndrome (OSAS) in children with sickle cell anemia (SCA).
methodsCross-sectional baseline data were analyzed from the Sleep and Asthma Cohort Study, a multicenter prospective study designed to evaluate the contribution of sleep and breathing abnormalities to SCA-related morbidity in children ages 4 to 18 years, unselected for OSAS symptoms or asthma. Multivariable logistic regression assessed the relationships between OSAS status on the basis of overnight in-laboratory polysomnography and putative risk factors obtained from questionnaires and direct measurements.
resultsParticipants included 243 children with a median age of 10 years; 50% were boys, 99% were of African heritage, and 95% were homozygous for β(S) hemoglobin. OSAS, defined by obstructive apnea hypopnea indices, was present in 100 (41%) or 25 (10%) children at cutpoints of ≥1 or ≥5, respectively. In univariate analyses, OSAS was associated with higher levels of habitual snoring, lower waking pulse oxygen saturation (Spo2), reduced lung function, less caretaker education, and non-preterm birth. Lower sleep-related Spo2 metrics were also associated with higher obstructive apnea hypopnea indices. In multivariable analyses, habitual snoring and lower waking Spo2 remained risk factors for OSAS in children with SCA.
conclusionsThe prevalence of OSAS in children with SCA is higher than in the general pediatric population. Habitual snoring and lower waking Spo2 values, data easily obtained in routine care, were the strongest OSAS risk factors. Because OSAS is a treatable condition with adverse health outcomes, greater efforts are needed to screen, diagnose, and treat OSAS in this high-risk, vulnerable population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.