Evidence map›Paper›PMID 25022540›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2015

At the interface of sensory and motor dysfunctions and Alzheimer's disease.

Mark W Albers, Grover C Gilmore, Jeffrey Kaye, Claire Murphy, Arthur Wingfield, David A Bennett, Adam L Boxer, Aron S Buchman, Karen J Cruickshanks, Davangere P Devanand and 18 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 328 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
328citing papers in PubMed, 5 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

328 citing papers in PubMed, 5 syntheses or guidelines pooled it, 587 citations in OpenAlex.

  1. Pooled it
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  18. A sensorimotor function construct to assess mild cognitive impairment risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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268 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 1 country.

Mark W AlbersDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: albers.mark@mgh.harvard.edu.
Grover C GilmoreJack, Joseph and Morton Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jeffrey KayeDepartment of Neurology, Oregon Heath & Science University, Portland, OR, USA.
Claire MurphySDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego State University, San Diego, CA, USA.
Arthur WingfieldVolen National Center for Complex Systems and Department of Psychology, Brandeis University, Waltham, MA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Adam L BoxerDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Karen J CruickshanksDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Davangere P DevanandDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Charles J DuffyDept. of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Christine M GallDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
George A GatesBloedel Hearing Research Center, University of Washington, Seattle, WA, USA.
Ann-Charlotte GranholmDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Center on Aging, Medical University of South Carolina, Charleston, SC, USA.
Takao HenschDepartment of Molecular & Cellular Biology, Harvard University, Cambridge, MA, USA.
Roee HoltzerDepartment of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Frank R LinDivision of Otology, Neurotology, & Skull Base Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ann C McKeeDepartments of Neurology and Pathology, Boston University School of Medicine, Bedford, MA, USA.
John C MorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Ronald C PetersenMayo Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA.
Lisa C SilbertDepartment of Neurology, Oregon Heath & Science University, Portland, OR, USA.
Robert G StrubleCenter for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL, USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research and Institute on Aging, the Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
Donald A WilsonEmotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Shunbin XuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Li I ZhangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rush University Medical Center · USHarvard University · USOregon Health & Science University · USYeshiva University · USBoston University · USBrandeis University · USCase Western Reserve University · USColumbia University · USInstitute on Aging · USJohns Hopkins University · USMassachusetts General Hospital · USMedical University of South Carolina · USNathan Kline Institute for Psychiatric Research · USSan Diego State University · USSouthern Illinois University School of Medicine · USUniversity of California, Irvine · USUniversity of California, San Francisco · USUniversity of Rochester · USUniversity of Southern California · USUniversity of Washington · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BOISE, LINDA · 1990 to 2019
$27.7M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Thalamic Modulation of Auditory Cortical Processing via LPR01DC008983 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Li I Zhang · 2007 to 2026
$8.7M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
Hearing Acuity, Cognitive Aging, and Memory for SpeechR01AG019714 · NIA · BRANDEIS UNIVERSITY · PI WINGFIELD, ARTHUR · 2002 to 2016
$4.0M
Chemosensory Perception &Psychophysics in the AgedR01AG004085 · NIA · SAN DIEGO STATE UNIVERSITY · PI MURPHY, CLAIRE L · 1986 to 2015
$3.4M
NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG004085NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019714NIA NIH HHS R01 AG031278NIA NIH HHS R01 AG037693NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG041795NIA NIH HHS R01 AG044920NIA NIH HHS RF1 AG015819NIDCD NIH HHS K23 DC011279NIDCD NIH HHS R01 DC008983NIH HHS DP2 OD006662NINDS NIH HHS R21 NS085711
6 · The paper itself

Abstract

Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.

Indexed as

AgingAlzheimer DiseaseDisease ProgressionEarly DiagnosisHumansMovement DisordersNational Institute on Aging (U.S.)Sensation DisordersUnited StatesAgingAlzheimer's diseaseAuditory functionMotorOlfactionSensoryVision

Identifiers

PMID25022540
PMCPMC4287457
OpenAlexW2148230634

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.