ReviewCurrent opinion in cell biology2014
Diverse and dynamic sources and sinks in gradient formation and directed migration.
Review in Current opinion in cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Finishing the egg.Genetics · 2024Article
- Modeling protein dynamics inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells.Frontiers in cell and developmental biology · 2022Article
- Born to Run? Diverse Modes of Epithelial Migration.Frontiers in cell and developmental biology · 2021Review
- Tissue topography steers migratingScience (New York, N.Y.) · 2020Article
- Dissemination of RasNature communications · 2020Article
- Article
- Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient.eLife · 2018Article
- Cell motility in cancer invasion and metastasis: insights from simple model organisms.Nature reviews. Cancer · 2018Review
- Cell-based computational model of early ovarian development in mice.Biology of reproduction · 2017Article
- Article
- Effects of 3D geometries on cellular gradient sensing and polarization.Physical biology · 2016Article
- Modeling and analysis of collective cell migration in an in vivo three-dimensional environment.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The front and rear of collective cell migration.Nature reviews. Molecular cell biology · 2016Review
- E-cadherin junctions as active mechanical integrators in tissue dynamics.Nature cell biology · 2015Review
- Cell traction in collective cell migration and morphogenesis: the chase and run mechanism.Cell adhesion & migration · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The traditional view of directional cell migration within a tissue is that it requires a gradient of a soluble attractive chemical that is stable in space and time due to the presence of a source and a sink. However, advances in live imaging technology and the ability to study cell migration in vivo have revealed that endogenous sources and sinks are typically far more varied and complex. Both sources and sinks can be made up of multiple tissues. During long-range migrations, cells tend to divide up their trajectories and follow different source signals in each segment. When a single source signal is used repeatedly in each segment, its expression is dynamically controlled. Source signals can also originate locally from neighboring migrating cells. Sinks are important in some cases but not all, to sculpt a permissive migratory path or allow cells to move from one intermediate target to another. Migrating cells themselves can function as sinks to create a gradient out of an initially uniform chemoattractant. These diverse ways of building sources and sinks allow different cell types to navigate distinct trajectories through the same embryo even as the whole embryo undergoes the dramatic changes in cell number, position, arrangement and fate that are the essence of development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.