ReviewSeminars in cell & developmental biology2014
Sizing it up: the mechanical feedback hypothesis of organ growth regulation.
Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- GαCell communication and signaling : CCS · 2025Article
- Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.Genes & development · 2025Review
- Piezo regulates epithelial topology and promotes precision in organ size control.Cell reports · 2024Article
- Reverse engineering morphogenesis through Bayesian optimization of physics-based models.NPJ systems biology and applications · 2024Article
- Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.Nature communications · 2024Article
- The Interaction of Mechanics and the Hippo Pathway inCancers · 2023Article
- Transducing compressive forces into cellular outputs in cancer and beyond.Life science alliance · 2023Review
- MAPPER: An Open-Source, High-Dimensional Image Analysis Pipeline Unmasks Differential Regulation ofFrontiers in genetics · 2022Article
- From spikes to intercellular waves: Tuning intercellular calcium signaling dynamics modulates organ size control.PLoS computational biology · 2021Article
- Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix.PLoS computational biology · 2020Article
- Gene expression atlas of a developing tissue by single cell expression correlation analysis.Nature methods · 2019Article
- Article
- Statistics of noisy growth with mechanical feedback in elastic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microfluidics on the fly: Inexpensive rapid fabrication of thermally laminated microfluidic devices for live imaging and multimodal perturbations of multicellular systems.Biomicrofluidics · 2019Article
- Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.Biophysical journal · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement.Nature communications · 2018Article
- Reverse-engineering organogenesis through feedback loops between model systems.Current opinion in biotechnology · 2018Review
- Release of Applied Mechanical Loading Stimulates Intercellular Calcium Waves in Drosophila Wing Discs.Biophysical journal · 2017Article
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The question of how the physical dimensions of animal organs are specified has long fascinated both experimentalists and computational scientists working in the field of developmental biology. Research over the last few decades has identified many of the genes and signaling pathways involved in organizing the emergent multi-scale features of growth and homeostasis. However, an integrated model of organ growth regulation is still unrealized due to the numerous feedback control loops found within and between intercellular signaling pathways as well as a lack of understanding of the exact role of mechanotransduction. Here, we review several computational and experimental studies that have investigated the mechanical feedback hypothesis of organ growth control, which postulates that mechanical forces are important for regulating the termination of growth and hence the final physical dimensions of organs. In particular, we highlight selected computational studies that have focused on the regulation of growth of the Drosophila wing imaginal disc. In many ways, these computational and theoretical approaches continue to guide experimental inquiry. We demonstrate using several examples how future progress in dissecting the crosstalk between the genetic and biophysical mechanisms controlling organ growth might depend on the close coupling between computational and experimental approaches, as well as comparison of growth control mechanisms in other systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.