ArticlePloS one2014
Effect of chromosome tethering on nuclear organization in yeast.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Multi-Scale Imaging of the Dynamic Organization of Chromatin.International journal of molecular sciences · 2023Review
- Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome.Science (New York, N.Y.) · 2023Article
- Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin.Epigenetics & chromatin · 2023Article
- Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome.bioRxiv : the preprint server for biology · 2023Article
- Review
- Suppression of telomere capping defects of Saccharomyces cerevisiae yku70 and yku80 mutants by telomerase.G3 (Bethesda, Md.) · 2021Article
- Article
- Article
- Mating-type switching by homology-directed recombinational repair: a matter of choice.Current genetics · 2019Review
- From dynamic chromatin architecture to DNA damage repair and back.Nucleus (Austin, Tex.) · 2018Review
- Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus.Nucleic acids research · 2017Article
- Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast.The EMBO journal · 2017Article
- Perspectives: using polymer modeling to understand the formation and function of nuclear compartments.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Review
- Position effects influencing intrachromosomal repair of a double-strand break in budding yeast.PloS one · 2017Article
- Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2016Article
- Chromosome-refolding model of mating-type switching in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Physical Modeling of Dynamic Coupling between Chromosomal Loci.Biophysical journal · 2016Article
- Chromosome position determines the success of double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Quantified effects of chromosome-nuclear envelope attachments on 3D organization of chromosomes.Nucleus (Austin, Tex.) · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Interphase chromosomes in Saccharomyces cerevisiae are tethered to the nuclear envelope at their telomeres and to the spindle pole body (SPB) at their centromeres. Using a polymer model of yeast chromosomes that includes these interactions, we show theoretically that telomere attachment to the nuclear envelope is a major determinant of gene positioning within the nucleus only for genes within 10 kb of the telomeres. We test this prediction by measuring the distance between the SPB and the silent mating locus (HML) on chromosome III in wild-type and mutant yeast strains that contain altered chromosome-tethering interactions. In wild-type yeast cells we find that disruption of the telomere tether does not dramatically change the position of HML with respect to the SPB, in agreement with theoretical predictions. Alternatively, using a mutant strain with a synthetic tether that localizes an HML-proximal site to the nuclear envelope, we find a significant change in the SPB-HML distance, again as predicted by theory. Our study quantifies the importance of tethering at telomeres on the organization of interphase chromosomes in yeast, which has been shown to play a significant role in determining chromosome function such as gene expression and recombination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.