Evidence map›Paper›PMID 25020004›Full record

ArticlePain2014

Estimating the burden of disease in chronic pain with and without neuropathic characteristics: does the choice between the EQ-5D and SF-6D matter?

Nicola Torrance, Kenny D Lawson, Ebenezer Afolabi, Michael I Bennett, Michael G Serpell, Kate M Dunn, Blair H Smith

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06719245 (Prevention of PostAmputation Pain With Targeted Muscle Reinnervation), which is not on this map. Cited by 44 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06719245 narecruitingnot on this mapstarted 2024, after this paper: background citation

Prevention of PostAmputation Pain With Targeted Muscle Reinnervation: A National, Multicenter, Randomized, Sham-controlled Superiority Trial, Comparing Standard Neurectomy With Targeted Muscle Reinnervation in Amputations of the Lower Extremities

TypeinterventionalSponsorLeiden University Medical CenterRan2024 to 2028Enrolled203ConditionsAmputation, Surgical, Phantom Limb Pain, Neuroma Amputation, SurgeryArmsTargeted Muscle Reinnervation (TMR), Standard neurectomy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Herbal medicinal products or preparations for neuropathic pain.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Pooled it
  5. Trial
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  8. Article
  9. Article
  10. Review
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  12. Comparative performance and mapping algorithms between EQ-5D-5L and SF-6Dv2 among the Chinese general population.The European journal of health economics : HEPAC : health economics in prevention and care · 2024
    Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nicola TorranceMedical Research Institute, University of Dundee, Dundee, Scotland, UK. Electronic address: n.torrance@dundee.ac.uk.
Kenny D LawsonCentre for Research Excellence in the Prevention of Chronic Conditions in Rural and Remote Populations, James Cook University, Townsville City, Australia.
Ebenezer AfolabiResearch Institute for Primary Care & Health Sciences, Keele University, Staffordshire, England, UK.
Michael I BennettAcademic Unit of Palliative Care, University of Leeds, Leeds, England, UK.
Michael G SerpellSchool of Medicine, University of Glasgow, Glasgow, Scotland, UK.
Kate M DunnResearch Institute for Primary Care & Health Sciences, Keele University, Staffordshire, England, UK.
Blair H SmithMedical Research Institute, University of Dundee, Dundee, Scotland, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The EQ-5D and Short Form (SF)12 are widely used generic health-related quality of life (HRQoL) questionnaires. They can be used to derive health utility index scores, on a scale where 0 is equivalent to death and 1 represents full health, with scores less than zero representing states "worse than death." We compared EQ-5D or SF-6D health utility index scores in patients with no chronic pain, and chronic pain with and without neuropathic characteristics (NC), and to explore their discriminant ability for pain severity. Self-reported health and chronic pain status was collected as part of a UK general population survey (n=4451). We found moderate agreement between individual dimensions of EQ-5D and SF-6D, with most highly correlated dimensions found for mental health and anxiety/depression, role limitations and usual activities, and pain and pain/discomfort. Overall 43% reported full health on the EQ-5D, compared with only 4.2% on the SF-6D. There were significant differences in mean utilities for chronic pain with NC (EQ-5D 0.47 vs SF-6D 0.62) and especially for severe pain (EQ-5D 0.33 vs SF-6D 0.58). On the EQ-5D, 17% of those with chronic pain with NC and 3% without NC scored "worse than death," a state which is not possible using the SF-6D. Health utilities derived from EQ-5D and SF-12/36 can discriminate between group differences for chronic pain with and without NC and greater pain severity. However, the instruments generate widely differing HRQoL scores for the same patient groups. The choice between using the EQ-5D or SF-6D matters greatly when estimating the burden of disease.

Indexed as

Cost of IllnessQuality of LifeAdolescentAdultAgedAged, 80 and overChronic PainFemaleHealth StatusHumansMaleMiddle AgedNeuralgiaPsychometricsSeverity of Illness IndexSurveys and QuestionnairesChronic painEQ-5DHealth-related quality of lifeHealth utilitiesNeuropathic painSF-6DS-LANSS

Identifiers

PMID25020004
PMCPMC4220009

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.