ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2014
Velocity alignment leads to high persistence in confined cells.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Confinement, Jamming, and Adhesion in Cancer Cells Dissociating from a Collectively Invading Strand.PRX life · 2025Article
- Migration and division in cell monolayers on substrates with topological defects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis.Biophysical journal · 2023Article
- Picking winners in cell-cell collisions: Wetting, speed, and contact.Physical review. E · 2022Article
- The role of vimentin-nuclear interactions in persistent cell motility through confined spaces.New journal of physics · 2021Article
- Enhanced persistence and collective migration in cooperatively aligning cell clusters.Biophysical journal · 2021Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Mechanisms of Cell Polarization.Current opinion in systems biology · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Modeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates.PLoS computational biology · 2016Article
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
- Emergent Collective Chemotaxis without Single-Cell Gradient Sensing.Physical review letters · 2016Article
- Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Geometry-Driven Polarity in Motile Amoeboid Cells.PloS one · 2014Article
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Authors and funding
2 authors.
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Abstract
Many cell types display random motility on two-dimensional substrates but crawl persistently in a single direction when confined in a microchannel or on an adhesive micropattern. Does this imply that the motility mechanism of confined cells is fundamentally different from that of unconfined cells? We argue that both free- and confined-cell migration may be described by a generic model of cells as "velocity-aligning" active Brownian particles previously proposed to solve a completely separate problem in collective cell migration. Our model can be mapped to a diffusive escape over a barrier and analytically solved to determine the cell's orientation distribution and repolarization rate. In quasi-one-dimensional confinement, velocity-aligning cells maintain their direction for times that can be exponentially larger than their persistence time in the absence of confinement. Our results suggest an important connection between single- and collective-cell migration: high persistence in confined cells corresponds with fast alignment of velocity to cell-cell forces.
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