ArticleAnalytical chemistry2014
Gold-nanoparticle-decorated silica nanorods for sensitive visual detection of proteins.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- New Frontiers for the Early Diagnosis of Cancer: Screening miRNAs Through the Lateral Flow Assay Method.Biosensors · 2025Review
- Sensitive Colorimetric Lateral Flow Assays Enabled by Platinum-Group Metal Nanoparticles with Peroxidase-Like Activities.Advanced healthcare materials · 2025Article
- Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development.International journal of nanomedicine · 2023Review
- Nanoelectrokinetic-assisted lateral flow assay for COVID-19 antibody test.Biosensors & bioelectronics · 2022Article
- Recent Advances in Silica-Nanomaterial-Assisted Lateral Flow Assay.Bioengineering (Basel, Switzerland) · 2022Review
- An immunochromatography strip with peroxidase-mimicking ferric oxyhydroxide nanorods-mediated signal amplification and readout.Mikrochimica acta · 2022Article
- Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay.Theranostics · 2022Review
- Rapid testing for coronavirus disease 2019 (COVID-19).MRS communications · 2022Review
- Review
- Gold nanoparticle-decorated metal organic frameworks on immunochromatographic assay for human chorionic gonadotropin detection.Mikrochimica acta · 2020Article
- 2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications.Micromachines · 2020Review
- Lateral flow biosensors based on the use of micro- and nanomaterials: a review on recent developments.Mikrochimica acta · 2019Review
- Magnetized Carbon Nanotube Based Lateral Flow Immunoassay for Visual Detection of Complement Factor B.Molecules (Basel, Switzerland) · 2019Article
- Carbon nanotube-based lateral flow immunoassay for ultrasensitive detection of proteins: application to the determination of IgG.Mikrochimica acta · 2019Article
- Peptidoglycan binding protein (PGBP)-modified magnetic nanobeads for efficient magnetic capturing of Staphylococcus aureus associated with sepsis in blood.Scientific reports · 2019Article
- Key Enabling Technologies for Point-of-Care Diagnostics.Sensors (Basel, Switzerland) · 2018Review
- Fluorescent carbon nanoparticle-based lateral flow biosensor for ultrasensitive detection of DNA.Biosensors & bioelectronics · 2017Article
- Development of quantitative immunochromatographic assay for rapid and sensitive detection of carbohydrate antigen 19-9 (CA 19-9) in human plasma.Journal of pharmaceutical and biomedical analysis · 2017Article
- Lateral flow assay for carbohydrate antigen 19-9 in whole blood by using magnetized carbon nanotubes.Mikrochimica acta · 2017Article
- Gold nanocage-based lateral flow immunoassay for immunoglobulin G.Mikrochimica acta · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report a rapid and highly sensitive approach based on gold-nanoparticle-decorated silica nanorods (GNP-SiNRs) label and lateral-flow strip biosensor (LFSB) for visually detecting proteins. Owing to its biocompatibility and convenient surface modification, SiNRs were used as carriers to load numerous GNPs, and the GNP-SiNRs were used as labels for the lateral-flow assay. The LFSB detection limit was lowered 50 times compared to the traditional GNP-based lateral-flow assay. Rabbit IgG was used as a model target to demonstrate the proof-of-concept. Sandwich-type immunoreactions were performed on the immunochromatographic strips, and the accumulation of GNP-SiNRs on the test zone produced the characteristic colored bands, enabling visual detection of proteins without instrumentation. The quantitative detection was performed by reading the intensities of the colored bands with a portable strip reader. The response of the optimized device was highly linear for the range of 0.05-2 ng mL(-1), and the detection limit was estimated to be 0.01 ng mL(-1). The GNP-SiNR-based LFSB, thus, offered an ultrasensitive method for rapidly detecting trace amounts of proteins. This method has a potential application with point-of-care screening for clinical diagnostics and biomedical research.
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Registered trials
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