Evidence map›Paper›PMID 25019378›Full record

ArticlePloS one2014

Exogenous Oct-4 inhibits lens transdifferentiation in the newt Notophthalmus viridescens.

Rital B Bhavsar, Panagiotis A Tsonis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rital B BhavsarDepartment of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America.
Panagiotis A TsonisDepartment of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America.
University of Dayton · US

Funding

PHS HHS NEI 10540
6 · The paper itself

Abstract

From the cocktail of four factors that were able to induce pluripotent stem cells from differentiated cells, Oct-4, c-Myc, Sox-2 and Klf4, only Oct-4 was not expressed during regeneration in newts. To explore the possible action of this stemness factor we developed an assay where we introduced exogenous Oct-4 protein to an in vitro system for lens regeneration in newts. We found that exogenous Oct-4 inhibits differentiation of iris pigmented epithelial cells into lens cells and also regulates Sox-2 and Pax-6, both important players during lens development. Thus, presence of Oct-4 hinders transdifferentiation of iris cells.

Indexed as

AnimalsCell TransdifferentiationEye ProteinsHomeodomain ProteinsLens, CrystallineOctamer Transcription Factor-3Paired Box Transcription FactorsPAX6 Transcription FactorRecombinant ProteinsRegenerationRepressor ProteinsSalamandridaeSOXB1 Transcription FactorsEye ProteinsHomeodomain ProteinsOctamer Transcription Factor-3Paired Box Transcription FactorsPAX6 Transcription FactorRecombinant ProteinsRepressor ProteinsSOXB1 Transcription Factors

Identifiers

PMID25019378
PMCPMC4097451
OpenAlexW2148887983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.