ArticlePloS one2014
Epigenetic inheritance, epimutation, and the response to selection.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Multi-locus models of deleterious epimutation-selection balance and the evolution of recombination modifiers.G3 (Bethesda, Md.) · 2026Article
- Mission SpaceX CRS-16 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger.iScience · 2024Article
- Deleterious mutation/epimutation-selection balance with and without inbreeding: a population (epi)genetics model.Genetics · 2024Article
- Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation.G3 (Bethesda, Md.) · 2024Article
- A conceptual framework for understanding stress-induced physiological and transgenerational effects on population responses to climate change.Evolution letters · 2024Article
- The Contribution of Epigenetics to Evolutionary Adaptation inPlants (Basel, Switzerland) · 2023Article
- Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation.The Journal of experimental biology · 2020Review
- Old Trade, New Tricks: Insights into the Spontaneous Mutation Process from the Partnering of Classical Mutation Accumulation Experiments with High-Throughput Genomic Approaches.Genome biology and evolution · 2019Review
- Simulated climate warming and mitochondrial haplogroup modulate testicular small non-coding RNA expression in the neotropical pseudoscorpion,Environmental epigenetics · 2018Article
- Quantitative epigenetics and evolution.Heredity · 2018Review
- Epigenetics and adaptive phenotypic variation between habitats in an asexual snail.Scientific reports · 2017Article
- The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution.Frontiers in microbiology · 2017Review
- Facilitation of environmental adaptation and evolution by epigenetic phenotype variation: insights from clonal, invasive, polyploid, and domesticated animals.Environmental epigenetics · 2017Review
- Genetic sources of population epigenomic variation.Nature reviews. Genetics · 2016Review
- Rate, spectrum, and evolutionary dynamics of spontaneous epimutations.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which mutation rates are assumed to be low relative to the strength of selection, the response to selection decays quickly due to a rapid lowering of parent-offspring epiallelic correlation. This effect is separate from the slowing response caused by a reduction in epigenetic variation. These results suggest that epigenetic variation may be less responsive to natural selection than is genetic variation, even in cases where levels of heritability appear similar.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.