ArticleACS nano2014
Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed.
- Radiolabeled AgScientific reports · 2026Article
- Theranostic Gold Nanoparticles Encapsulated in a PEGylated Liposome as an Effective Radiosensitizer for Cancer Radiation Therapy.ACS applied bio materials · 2025Article
- Deep learning for automatic organ and tumor segmentation in nanomedicine pharmacokinetics.Theranostics · 2024Article
- Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging.Drug delivery and translational research · 2023Review
- Challenges and advances for glioma therapy based on inorganic nanoparticles.Materials today. Bio · 2023Review
- A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach.Pharmaceutics · 2023Review
- Preparation and Evaluation ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Methods for Radiolabelling Nanoparticles: PET Use (Part 2).Biomolecules · 2022Review
- Engineered Aurotherapy for the Multimodal Treatment of Glioblastoma.Brain tumor research and treatment · 2022Review
- Nanotechnology-Based Combinatorial Anti-Glioblastoma Therapies: Moving from Terminal to Treatable.Pharmaceutics · 2022Review
- Core-shell structured gold nanoparticles as carrier forEJNMMI radiopharmacy and chemistry · 2022Article
- Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine.International journal of molecular sciences · 2022Review
- Application of nanomaterials in diagnosis and treatment of glioblastoma.Frontiers in chemistry · 2022Review
- Recent Advances in the Development of Noble Metal NPs for Cancer Therapy.Bioinorganic chemistry and applications · 2022Review
- Industrialization's eye view on theranostic nanomedicine.Frontiers in chemistry · 2022Review
- Construction of nanomaterials as contrast agents or probes for glioma imaging.Journal of nanobiotechnology · 2021Review
- αNanomaterials (Basel, Switzerland) · 2021Article
- Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer.Materials (Basel, Switzerland) · 2020Review
- Dual-targeted photothermal agents for enhanced cancer therapy.Chemical science · 2020Review
- Cation Exchange Protocols to Radiolabel Aqueous Stabilized ZnS, ZnSe, and CuFeSAdvanced functional materials · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery and localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential to optimize therapeutic protocols to achieve individualized medicine and avoid side effects. Coupling radiometals to Au NMs via a chelator faces the challenges of possible detachment of the radiometals as well as surface property changes of the NMs. In this study, we reported a simple and general chelator-free (64)Cu radiolabeling method by chemically reducing (64)Cu on the surface of polyethylene glycol (PEG)-stabilized Au NMs regardless of their shape and size. Our (64)Cu-integrated NMs are proved to be radiochemically stable and can provide an accurate and sensitive localization of NMs through noninvasive PET imaging. We further integrated (64)Cu onto arginine-glycine-aspartic acid (RGD) peptide modified Au nanorods (NRs) for tumor theranostic application. These NRs showed high tumor targeting ability in a U87MG glioblastoma xenograft model and were successfully used for PET image-guided photothermal therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.