A functional system for high-content screening of neuromuscular junctions

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

1. An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing.Current research in toxicology · 2025
   Article
2. The Activity of Plant-Derived Ren's Oligopeptides-1 against the Pseudorabies Virus.Animals : an open access journal from MDPI · 2022
   Article
3. Current Progress in the Creation, Characterization, and Application of Human Stem Cell-derived in Vitro Neuromuscular Junction Models.Stem cell reviews and reports · 2022
   Review
4. hiPSC-Derived Schwann Cells Influence Myogenic Differentiation in Neuromuscular Cocultures.Cells · 2021
   Article
5. Creating stem cell-derived neuromuscular junctions in vitro.Muscle & nerve · 2021
   Review
6. A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics.Frontiers in cell and developmental biology · 2021
   Article
7. Neuromuscular Development and Disease: Learning FromFrontiers in cell and developmental biology · 2021
   Review
8. Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS).Frontiers in cell and developmental biology · 2021
   Review
9. A Human-Based Functional NMJ System for Personalized ALS Modeling and Drug Testing.Advanced therapeutics · 2020
   Article
10. In vitro models of neuromuscular junctions and their potential for novel drug discovery and development.Expert opinion on drug discovery · 2020
    Review
11. A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment.Biotechnology and bioengineering · 2020
    Article
12. On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease.Nature protocols · 2020
    Article
13. Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes.iScience · 2019
    Review
14. Engineered skeletal muscles for disease modeling and drug discovery.Biomaterials · 2019
    Review
15. Development and application of human skeletal muscle microphysiological systems.Lab on a chip · 2018
    Review
16. Bioinspired Three-Dimensional Human Neuromuscular Junction Development in Suspended Hydrogel Arrays.Tissue engineering. Part C, Methods · 2018
    Article
17. Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics.Biomaterials · 2018
    Article
18. Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.Advanced healthcare materials · 2018
    Review
19. A functional human motor unit platform engineered from human embryonic stem cells and immortalized skeletal myoblasts.Stem cells and cloning : advances and applications · 2018
    Article
20. Functional analysis of human intrafusal fiber innervation by human γ-motoneurons.Scientific reports · 2017
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

4 authors at 1 institution in 1 country.

Funding

Abstract