Evidence map›Paper›PMID 25019074›Full record

ReviewHepatobiliary surgery and nutrition2014

The multifaceted nature of retinoid transport and metabolism.

Yang Li, Nuttaporn Wongsiriroj, William S Blaner

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hepatobiliary surgery and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Micronutrient status of patients with diabetic foot: A systematic review.Asia Pacific journal of clinical nutrition · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Micronutrient deficiencies in hepatic cirrhosis: Navigating challenges to assessment and implications for clinical management: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Vitamin A deficiency attenuates cardiac rupture inFrontiers in cardiovascular medicine · 2025
    Article
  16. Review
  17. Review
  18. Levels of retinol and retinoic acid in pancreatic cancer, type-2 diabetes and chronic pancreatitis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2024
    Article
  19. Review
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yang Li1 Columbia College, Columbia University, New York, NY, USA ; 2 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand ; 3 College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Nuttaporn Wongsiriroj1 Columbia College, Columbia University, New York, NY, USA ; 2 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand ; 3 College of Physicians and Surgeons, Columbia University, New York, NY, USA.
William S Blaner1 Columbia College, Columbia University, New York, NY, USA ; 2 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand ; 3 College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Columbia University · US

Funding

Postprandial Vitamin AR01DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2004 to 2023
$7.0M
Retinoid Metabolism and Alcohol Induced DiseaseRC2AA019413 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2009 to 2010
$1.8M
Vitamin A Storage and MetabolismR01DK079221 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2007 to 2010
$1.3M
Alcohol Intake and Hepatic Fat MetabolismR21AA020561 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, LI-SHIN · 2011 to 2012
$420k
Alcohol Consumption and Brown Adipose TissueR21AA021336 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2013 to 2014
$414k
NIAAA NIH HHS R21 AA020561NIAAA NIH HHS R21 AA021336NIAAA NIH HHS RC2 AA019413NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK079221
6 · The paper itself

Abstract

Since their discovery over a century ago, retinoids have been the most studied of the fat-soluble vitamins. Unlike most vitamins, retinoids are stored at relatively high concentrations in the body to buffer against nutritional insufficiency. Until recently, it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein (RBP4). More recent findings, however, indicate that retinoids can be delivered to tissues through multiple overlapping delivery pathways, involving chylomicrons, very low density lipoprotein (VLDL) and low density lipoprotein (LDL), retinoic acid bound to albumin, water soluble β-glucuronides of retinol and retinoic acid, and provitamin A carotenoids. This review will focus on explaining this evolving understanding of retinoid metabolism and transport within the body.

Indexed as

beta-carotenehypervitaminosis Ahypovitaminosis Ametabolic diseaseretinol-binding protein (RBP4)transthyretin (TTR)Vitamin A

Identifiers

PMID25019074
PMCPMC4073323
OpenAlexW1864661089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.