ReviewFrontiers in cellular and infection microbiology2014
Acquiring and maintaining a normal oral microbiome: current perspective.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
144 citing papers in PubMed, 2 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Alterations of oral microbiome in oral potentially malignant disorders: a systematic review.BMC oral health · 2026Pooled it
- The Human Respiratory Microbiome: Current Understandings and Future Directions.American journal of respiratory cell and molecular biology · 2023Pooled it
- A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology.Scientific reports · 2017Trial
- Review
- Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.Bioactive materials · 2026Article
- A mechanistic framework linking the oral microbiome to Alzheimer's disease through neuroinflammation.Journal of Alzheimer's disease : JAD · 2026Review
- Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review.International dental journal · 2026Review
- Population-scale characterization of the oral microbiome and associations with metabolic health.Nature communications · 2026Article
- Comparative microbiome profiling of betel quid chewers and non-chewers to identify dysbiotic microbial signatures.Scientific reports · 2026Article
- Exploring the Therapeutic Potential of Diverse Bacterial Strains for Management of Periodontal Diseases.Probiotics and antimicrobial proteins · 2026Review
- The Clinical Role of the Adenoid Microbiome in the Development of Adenoid Hypertrophy and Otitis Media with Effusion.Journal of clinical medicine · 2026Article
- Harnessing Microbiome-Mediated and Macrophage-Driven Mechanisms for Oral Wound Healing.Microorganisms · 2026Review
- Effect of periodontal therapy on the oral microbiome and lung function: an intervention study.Frontiers in cellular and infection microbiology · 2026Article
- Potential value of oral Mogibacterium in major depressive disorder.Frontiers in cellular and infection microbiology · 2026Article
- Shotgun metagenomic analysis of the tongue-coating microbiome reveals oral microbes and their functions in older adults with dementia.Journal of oral microbiology · 2026Article
- Developmental ecology of the infant oral ecosystem: a framework for early childhood caries.Frontiers in oral health · 2026Review
- Periodontal Medicine 2.0: a framework for evidence-calibrated, integrated and patient-centred care.Frontiers in dental medicine · 2026Article
- Oral Microbiome in Oral Cancer Research from Sampling to Analysis: Strategies, Challenges, and Recommendations.Cancers · 2025Review
- Actifensin Evolution in the Human Oral Cavity over the Past 100,000 Years.Journal of the American Chemical Society · 2025Article
- Associations between mediterranean diet adherence, binge eating behavior, and oral health-related quality of life in adults.Journal of health, population, and nutrition · 2025Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis-a microbial shift toward a disease, e.g., periodontitis or caries. Although processes that underlie oral diseases have been studied extensively, processes involved in maintaining of a normal, healthy microbiome are poorly understood. In this review we present our hypothesis on how a healthy oral microbiome is acquired and maintained. We introduce our view on the prenatal development of tolerance for the normal oral microbiome: we propose that development of fetal tolerance toward the microbiome of the mother during pregnancy is the major factor for a successful acquisition of a normal microbiome. We describe the processes that influence the establishment of such microbiome, followed by our perspective on the process of sustaining a healthy oral microbiome. We divide microbiome-maintenance factors into host-derived and microbe-derived, while focusing on the host. Finally, we highlight the need and directions for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.