Evidence map›Paper›PMID 25018786›Full record

ReviewBiomolecular concepts2014

Control of cellular motility by neuropilin-mediated physical interactions.

Xiaobo Li, Matthew W Parker, Craig W Vander Kooi

Open access · hybridAbstract readReview
In one paragraph

Review in Biomolecular concepts, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Neuropilin Functions as an Essential Cell Surface Receptor.The Journal of biological chemistry · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xiaobo Li
Matthew W Parker
Craig W Vander Kooi
University of Kentucky · US

Funding

Mechanism of Neuropilin Dependent AngiogenesisR01GM094155 · NIGMS · UNIVERSITY OF KENTUCKY · PI VANDER KOOI, CRAIG · 2010 to 2014
$1.3M
NIGMS NIH HHS R01 GM094155NIGMS NIH HHS R01GM094155
6 · The paper itself

Abstract

The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multistep process of cellular motility through integration of ligand binding and receptor signaling. At a molecular level, the role of Nrp in migration is intimately connected to the control of adhesive interactions and cytoskeletal reorganization. Here, we review the physiological role of Nrp in cellular adhesion and motility in the cardiovascular and nervous systems. We also discuss the emerging pathological role of Nrp in tumor cell migration and metastasis, providing motivation for continued efforts toward developing Nrp inhibitors.

Indexed as

AnimalsCardiovascular SystemCell AdhesionCell MovementHumansNeoplasmsNervous SystemNeuropilinsSemaphorinsSignal TransductionVascular Endothelial Growth Factor ANeuropilinsSemaphorinsVascular Endothelial Growth Factor A

Identifiers

PMID25018786
PMCPMC4086447
OpenAlexW2049553831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.