ArticleFrontiers in microbiology2014
Exploring the molecular mechanisms of electron shuttling across the microbe/metal space.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 93 citations in OpenAlex.
- Cell-Surface Inter-Cytochrome Electron Transfer Limits Biofilm Electron Conduction Kinetics inJournal of the American Chemical Society · 2025Article
- Microbial respiration - a biomineral perspective.FEMS microbiology ecology · 2025Review
- Dynamic synthesis and transport of phenazine-1-carboxylic acid to boost extracellular electron transfer rate.Nature communications · 2025Article
- Electron transfer in multicentre redox proteins: from fundamentals to extracellular electron transfer.Bioscience reports · 2025Review
- Extracellular electron transfer genes expressed by candidate flocking bacteria in cable bacteria sediment.mSystems · 2025Article
- Overlap and differences between the inward and outward electron transfer pathways in Shewanella oneidensis.FEMS microbiology letters · 2025Article
- Optimizing the Metal Bioreduction Process in Recombinant Shewanella azerbaijanica Bacteria: A Novel Approach via mtrC Gene Cloning and Nitrate-Reducing Pathway Destruction.Molecular biotechnology · 2024Article
- Carbon source priority and availability limit bidirectional electron transfer in freshwater mixed culture electrochemically active bacterial biofilms.Bioresources and bioprocessing · 2023Article
- Article
- Deciphering Molecular Factors That Affect Electron Transfer at the Cell Surface of Electroactive Bacteria: The Case of OmcA fromMicroorganisms · 2022Article
- Single molecule tracking of bacterial cell surface cytochromes reveals dynamics that impact long-distance electron transport.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Outer MembraneApplied and environmental microbiology · 2020Article
- How does electron transfer occur in microbial fuel cells?World journal of microbiology & biotechnology · 2020Review
- Article
- Effects of Flavin-Goethite Interaction on Goethite Reduction byFrontiers in microbiology · 2019Article
- Electrochemical Detection of pH-Responsive Grafted Catechol and Immobilized CytochromeACS omega · 2018Article
- Structural modeling of an outer membrane electron conduit from a metal-reducing bacterium suggests electron transfer via periplasmic redox partners.The Journal of biological chemistry · 2018Article
- Ultrastructure ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Functional Mechanisms and Application of Electron Shuttles in Extracellular Electron Transfer.Current microbiology · 2018Review
- Outer membrane cytochromes/flavin interactions in Shewanella spp.-A molecular perspective.Biointerphases · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dissimilatory metal reducing organisms play key roles in the biogeochemical cycle of metals as well as in the durability of submerged and buried metallic structures. The molecular mechanisms that support electron transfer across the microbe-metal interface in these organisms remain poorly explored. It is known that outer membrane proteins, in particular multiheme cytochromes, are essential for this type of metabolism, being responsible for direct and indirect, via electron shuttles, interaction with the insoluble electron acceptors. Soluble electron shuttles such as flavins, phenazines, and humic acids are known to enhance extracellular electron transfer. In this work, this phenomenon was explored. All known outer membrane decaheme cytochromes from Shewanella oneidensis MR-1 with known metal terminal reductase activity and a undecaheme cytochrome from Shewanella sp. HRCR-6 were expressed and purified. Their interactions with soluble electron shuttles were studied using stopped-flow kinetics, NMR spectroscopy, and molecular simulations. The results show that despite the structural similarities, expected from the available structural data and sequence homology, the detailed characteristics of their interactions with soluble electron shuttles are different. MtrC and OmcA appear to interact with a variety of different electron shuttles in the close vicinity of some of their hemes, and with affinities that are biologically relevant for the concentrations typical found in the medium for this type of compounds. All data support a view of a distant interaction between the hemes of MtrF and the electron shuttles. For UndA a clear structural characterization was achieved for the interaction with AQDS a humic acid analog. These results provide guidance for future work of the manipulation of these proteins toward modulation of their role in metal attachment and reduction.
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