ArticleFrontiers in aging neuroscience2014
Aging induced loss of complexity and dedifferentiation: consequences for coordination dynamics within and between brain, muscular and behavioral levels.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
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- Reduced Motor Individuality in Older Adults Revealed by Network-Based Gait Fingerprinting.Medicina (Kaunas, Lithuania) · 2025Article
- Rewiring the aging brain: exergaming modulates brain complexity in older adults.Frontiers in aging neuroscience · 2025Article
- Behavioural stochastic resonance across the lifespan.Cognitive, affective & behavioral neuroscience · 2024Article
- Alpha band oscillations in common synaptic input are explanatory of the complexity of isometric knee extensor muscle torque signals.Experimental physiology · 2024Article
- Force Fluctuations During Role-Differentiated Bimanual Movements Reflect Cognitive Impairments in Older Adults: A Cohort Sequential Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- EEG spectral attractors identify a geometric core of brain dynamics.Patterns (New York, N.Y.) · 2024Article
- Spatial variability and directional shifts in postural control in Parkinson's disease.Clinical parkinsonism & related disorders · 2024Article
- Towards Human-like Walking with Biomechanical and Neuromuscular Control Features: Personalized Attachment Point Optimization Method of Cable-Driven Exoskeleton.Frontiers in aging neuroscience · 2024Article
- Revisiting nonlinearity of heart rate variability in healthy aging.Scientific reports · 2023Article
- White-matter degradation and dynamical compensation support age-related functional alterations in human brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Falls caused by balance disorders in the elderly with multiple systems involved: Pathogenic mechanisms and treatment strategies.Frontiers in neurology · 2023Review
- Aging and skeletal muscle force control: Current perspectives and future directions.Scandinavian journal of medicine & science in sports · 2022Review
- Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms.Frontiers in aging · 2022Review
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence demonstrates that aging not only leads to structural and functional alterations of individual components of the neuro-musculo-skeletal system (NMSS) but also results in a systemic re-organization of interactions within and between the different levels and functional domains. Understanding the principles that drive the dynamics of these re-organizations is an important challenge for aging research. The present Hypothesis and Theory paper is a contribution in this direction. We propose that age-related declines in brain and behavior that have been characterized in the literature as dedifferentiation and the loss of complexity (LOC) are: (i) synonymous; and (ii) integrated. We argue that a causal link between the aforementioned phenomena exists, evident in the dynamic changes occurring in the aging NMSS. Through models and methods provided by a dynamical systems approach to coordination processes in complex living systems, we: (i) formalize operational hypotheses about the general principles of changes in cross-level and cross-domain interactions during aging; and (ii) develop a theory of the aging NMSS based on the combination of the frameworks of coordination dynamics (CD), dedifferentiation, and LOC. Finally, we provide operational predictions in the study of aging at neural, muscular, and behavioral levels, which lead to testable hypotheses and an experimental agenda to explore the link between CD, LOC and dedifferentiation within and between these different levels.
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