Evidence map›Paper›PMID 25018719›Full record

ReviewFrontiers in human neuroscience2014

Brain plasticity-based therapeutics.

Michael M Merzenich, Thomas M Van Vleet, Mor Nahum

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 109 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04081090 naterminatednot on this mapstarted 2019, after this paper: background citation

Structured Cognitive Therapy to Improve Neurocognitive Dysfunction in Older Intensive Care Unit Sepsis Survivors

TypeinterventionalSponsorMedical College of WisconsinRan2019 to 2020Enrolled1ConditionsNeurocognitive DisordersArmsBrain HQ Cognitive Modules
NCT04210778 nacompletednot on this mapstarted 2018, after this paper: background citation

Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment

TypeinterventionalSponsorHadassah Medical OrganizationRan2018 to 2022Enrolled90ConditionsCognitive Decline, CancerArmsCognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic review about the importance of neuropsychological features in heart failure: is at heart the only failure?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  11. Home-Based, Adaptive Cognitive Training for Cognitively Normal Older adults: Initial Efficacy Trial.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael M MerzenichPosit Science Corporation San Francisco, CA, USA.
Thomas M Van VleetPosit Science Corporation San Francisco, CA, USA ; Medical Research, Department of Veteran Affairs Martinez, CA, USA.
Mor NahumPosit Science Corporation San Francisco, CA, USA ; Department of Optometry, University of California at Berkeley Berkeley, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary objective of this review article is to summarize how the neuroscience of brain plasticity, exploiting new findings in fundamental, integrative and cognitive neuroscience, is changing the therapeutic landscape for professional communities addressing brain-based disorders and disease. After considering the neurological bases of training-driven neuroplasticity, we shall describe how this neuroscience-guided perspective distinguishes this new approach from (a) the more-behavioral, traditional clinical strategies of professional therapy practitioners, and (b) an even more widely applied pharmaceutical treatment model for neurological and psychiatric treatment domains. With that background, we shall argue that neuroplasticity-based treatments will be an important part of future best-treatment practices in neurological and psychiatric medicine.

Indexed as

agingbrain plasticitycomputerized traininghemispatial neglectneuroplasticityschizophrenia

Identifiers

PMID25018719
PMCPMC4072971

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.