ReviewFrontiers in human neuroscience2014
Finding an optimal rehabilitation paradigm after stroke: enhancing fiber growth and training of the brain at the right moment.
Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What do randomized controlled trials say about virtual rehabilitation in stroke? A systematic literature review and meta-analysis of upper-limb and cognitive outcomes.Journal of neuroengineering and rehabilitation · 2018Pooled it
- Enhancing spontaneous recovery after stroke: a randomized controlled trial.Brain communications · 2026Trial
- Fluoxetine does not influence response to continuous theta burst stimulation in human motor cortex.Neuropsychopharmacology reports · 2025Trial
- Trial
- Trial
- Changes of Brain Connectivity in the Primary Motor Cortex After Subcortical Stroke: A Multimodal Magnetic Resonance Imaging Study.Medicine · 2016Trial
- Do post-stroke patients benefit from robotic verticalization? A pilot-study focusing on a novel neurophysiological approach.Restorative neurology and neuroscience · 2015Trial
- Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation.Signal transduction and targeted therapy · 2026Article
- The impact of stroke on intramuscular connective tissue in mice.Frontiers in neurology · 2026Article
- "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A structural causal model for robot-assisted upper-limb neurorehabilitation.Frontiers in rehabilitation sciences · 2026Article
- Article
- A Personalized Multimodal BCI-Soft Robotics System for Rehabilitating Upper Limb Function in Chronic Stroke Patients.Biomimetics (Basel, Switzerland) · 2025Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- A role for astrocytic insulin-like growth factor I receptors in the response to ischemic insult.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Novel subsets of peripheral immune cells associated with promoting stroke recovery in mice.CNS neuroscience & therapeutics · 2024Article
- Effect of acupuncture combined with rehabilitation training on sensory impairment of patients with stroke: a network meta-analysis.BMC complementary medicine and therapies · 2024Article
- The potential of a combined cell-based therapy and rehabilitation approach for stroke recovery.Neuroprotection (Chichester, England) · 2023Review
- Home-Based Virtual Reality Exergame Program after Stroke Rehabilitation for Patients with Stroke: A Study Protocol for a Multicenter, Randomized Controlled Trial.Life (Basel, Switzerland) · 2023Article
- The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery.Biomolecules · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After stroke the central nervous system reveals a spectrum of intrinsic capacities to react as a highly dynamic system which can change the properties of its circuits, form new contacts, erase others, and remap related cortical and spinal cord regions. This plasticity can lead to a surprising degree of spontaneous recovery. It includes the activation of neuronal molecular mechanisms of growth and of extrinsic growth promoting factors and guidance signals in the tissue. Rehabilitative training and pharmacological interventions may modify and boost these neuronal processes, but almost nothing is known on the optimal timing of the different processes and therapeutic interventions and on their detailed interactions. Finding optimal rehabilitation paradigms requires an optimal orchestration of the internal processes of re-organization and the therapeutic interventions in accordance with defined plastic time windows. In this review we summarize the mechanisms of spontaneous plasticity after stroke and experimental interventions to enhance growth and plasticity, with an emphasis on anti-Nogo-A immunotherapy. We highlight critical time windows of growth and of rehabilitative training and consider different approaches of combinatorial rehabilitative schedules. Finally, we discuss potential future strategies for designing repair and rehabilitation paradigms by introducing a "3 step model": determination of the metabolic and plastic status of the brain, pharmacological enhancement of its plastic mechanisms, and stabilization of newly formed functional connections by rehabilitative training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.