Evidence map›Paper›PMID 25018714›Full record

ReviewFrontiers in human neuroscience2014

Non-invasive brain stimulation in neurorehabilitation: local and distant effects for motor recovery.

Sook-Lei Liew, Emilliano Santarnecchi, Ethan R Buch, Leonardo G Cohen

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06396715 (Optimal Therapeutic Dose of Transcranial Direct Current Stimulation for Functional Upper Limb Recovery in People With Stroke), which is not on this map. Cited by 104 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 10 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06396715 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Optimal Therapeutic Dose of Transcranial Direct Current Stimulation for Functional Upper Limb Recovery in People With Stroke: Multicenter Randomized Clinical Trial

TypeinterventionalSponsorUniversity of ChileRan2024 to 2025Enrolled36ConditionsStroke, Neurologic DeficitsArmsTranscranial direct current stimulation
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 10 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
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  5. Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
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  7. Effect of non-invasive brain stimulation on conscious disorder in patients after brain injury: a network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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  17. Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.Neuromodulation : journal of the International Neuromodulation Society · 2018
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Sook-Lei LiewHuman Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH Bethesda, MD, USA.
Emilliano SantarnecchiDepartment of Medicine, Surgery and Neuroscience, University of Siena Siena, Italy.
Ethan R BuchHuman Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH Bethesda, MD, USA ; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences Bethesda, MD, USA.
Leonardo G CohenHuman Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, NIH Bethesda, MD, USA ; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences Bethesda, MD, USA.
Center for Neuroscience and Regenerative Medicine · USNational Institute of Neurological Disorders and Stroke · USUniformed Services University of the Health Sciences · USUniversity of Siena · IT

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
6 · The paper itself

Abstract

Non-invasive brain stimulation (NIBS) may enhance motor recovery after neurological injury through the causal induction of plasticity processes. Neurological injury, such as stroke, often results in serious long-term physical disabilities, and despite intensive therapy, a large majority of brain injury survivors fail to regain full motor function. Emerging research suggests that NIBS techniques, such as transcranial magnetic (TMS) and direct current (tDCS) stimulation, in association with customarily used neurorehabilitative treatments, may enhance motor recovery. This paper provides a general review on TMS and tDCS paradigms, the mechanisms by which they operate and the stimulation techniques used in neurorehabilitation, specifically stroke. TMS and tDCS influence regional neural activity underlying the stimulation location and also distant interconnected network activity throughout the brain. We discuss recent studies that document NIBS effects on global brain activity measured with various neuroimaging techniques, which help to characterize better strategies for more accurate NIBS stimulation. These rapidly growing areas of inquiry may hold potential for improving the effectiveness of NIBS-based interventions for clinical rehabilitation.

Indexed as

neurorehabilitationnon-invasive brain stimulationstroketranscranial direct current stimulation (tDCS)transcranial magnetic stimulation

Identifiers

PMID25018714
PMCPMC4072967
OpenAlexW2030769017

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.