Trial reportAcademic radiology2014
Longitudinal changes in airway remodeling and air trapping in severe asthma.
Trial report in Academic radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study.Advances in therapy · 2023Trial
- Quantitative Tomographic Analysis as a Prognostic Tool in Connective Tissue Disease-Associated Interstitial Lung Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Does the Reversal and Normalization of Airway and Pulmonary Vascular Remodeling Accompany Asthma Remission?Chest · 2025Article
- Tezepelumab can Restore Normal Lung Function in Patients with Severe, Uncontrolled Asthma: Pooled Results from the PATHWAY and NAVIGATOR Studies.Pulmonary therapy · 2025Article
- Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.American journal of respiratory and critical care medicine · 2024Article
- Article
- Airway remodeling heterogeneity in asthma and its relationship to disease outcomes.Frontiers in physiology · 2023Review
- Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts.Radiology · 2022Observational
- The emerging role of quantitative imaging in asthma.The British journal of radiology · 2022Article
- Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3.The Journal of allergy and clinical immunology · 2021Article
- Lung density analysis using quantitative computed tomography in children with pectus excavatum.Polish journal of radiology · 2021Article
- Status and prospects: personalized treatment and biomarker for airway remodeling in asthma.Journal of thoracic disease · 2020Review
- Postbronchodilator lung function improvements with benralizumab for patients with severe asthma.Allergy · 2020Article
- Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history.Scientific reports · 2018Article
- Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI.Academic radiology · 2018Article
- Phenotype-Driven Therapeutics in Severe Asthma.Current allergy and asthma reports · 2017Review
- Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil.Clinical and translational allergy · 2017Article
- Quantitative CT characterization of pediatric lung development using routine clinical imaging.Pediatric radiology · 2016Article
- The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma.Experimental & molecular medicine · 2015Article
- Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesPrevious cross-sectional studies have demonstrated that airway wall thickness and air trapping are greater in subjects with severe asthma than in those with mild-to-moderate asthma. However, a better understanding of how airway remodeling and lung density change over time is needed. This study aimed to evaluate predictors of airway wall remodeling and change in lung function and lung density over time in severe asthma. MATERIALS AND
methodsPhenotypic characterization and quantitative multidetector-row computed tomography (MDCT) of the chest were performed at baseline and ∼2.6 years later in 38 participants with asthma (severe n = 24 and mild-to-moderate n = 14) and nine normal controls from the Severe Asthma Research Program.
resultsSubjects with severe asthma had a significant decline in postbronchodilator forced expiratory volume in 1 second percent (FEV1%) predicted over time (P < .001). Airway wall thickness measured by MDCT was increased at multiple airway generations in severe asthma compared to mild-to-moderate asthma (wall area percent [WA%]: P < .05) and normals (P < .05) at baseline and year 2. Over time, there was an increase in WA% and wall thickness percent (WT%) in all subjects (P = .030 and .009, respectively) with no change in emphysema-like lung or air trapping. Baseline prebronchodilator FEV1% inversely correlated with WA% and WT% (both P < .05). In a multivariable regression model, baseline WA%, race, and health care utilization were predictors of subsequent airway remodeling.
conclusionsSevere asthma subjects have a greater decline in lung function over time than normal subjects or those with mild-to-moderate asthma. MDCT provides a noninvasive measure of airway wall thickness that may predict subsequent airway remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.