ArticleMolecular & general genetics : MGG1989
Glucose repression of LAC gene expression in yeast is mediated by the transcriptional activator LAC9.
Article in Molecular & general genetics : MGG, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Natural trait variation across Saccharomycotina species.FEMS yeast research · 2024Review
- Accessible Type 2 diabetes medication through stable expression of Exendin-4 inFrontiers in systems biology · 2024Article
- Proteomic and functional consequences of hexokinase deficiency in glucose-repressible Kluyveromyces lactis.Molecular & cellular proteomics : MCP · 2014Article
- Regulations of sugar transporters: insights from yeast.Current genetics · 2013Review
- Dynamic analysis of the KlGAL regulatory system in Kluyveromyces lactis: a comparative study with Saccharomyces cerevisiae.Systems and synthetic biology · 2011Article
- Secretion of human serum albumin by Kluyveromyces lactis overexpressing KlPDI1 and KlERO1.Applied and environmental microbiology · 2005Article
- Improved production of heterologous proteins by a glucose repression-defective mutant of Kluyveromyces lactis.Applied and environmental microbiology · 2004Article
- The S. Cerevisiae HAP complex, a key regulator of mitochondrial function, coordinates nuclear and mitochondrial gene expression.Comparative and functional genomics · 2003Article
- Respiration-dependent utilization of sugars in yeasts: a determinant role for sugar transporters.Journal of bacteriology · 2002Article
- Feedback regulation of glucose transporter gene transcription in Kluyveromyces lactis by glucose uptake.Journal of bacteriology · 2001Article
- Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1.Journal of bacteriology · 2001Article
- RAG4 gene encodes a glucose sensor in Kluyveromyces lactis.Genetics · 2001Article
- Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Glucose represses the lactose-galactose regulon in Kluyveromyces lactis through a SNF1 and MIG1- dependent pathway that modulates galactokinase (GAL1) gene expression.Nucleic acids research · 1997Article
- FOG1 and FOG2 genes, required for the transcriptional activation of glucose-repressible genes of Kluyveromyces lactis, are homologous to GAL83 and SNF1 of saccharomyces cerevisiae.Current genetics · 1996Article
- Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis.Current genetics · 1995Article
- Carbon catabolite repression in Kluyveromyces lactis: isolation and characterization of the KIDLD gene encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase.Molecular & general genetics : MGG · 1994Article
- Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon.Molecular and cellular biology · 1993Article
- Autoregulation of GAL4 transcription is essential for rapid growth of Kluyveromyces lactis on lactose and galactose.Nucleic acids research · 1993Article
- The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAG1 in Kluyveromyces lactis.Molecular and cellular biology · 1993Article
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Abstract
In the yeast Kluyveromyces lactis the beta-galactosidase gene is induced by lactose or galactose. As shown here it can also be repressed by glucose but only in some strains. When the LAC9 gene of a repressible strain is substituted by an allele of a non-repressible strain, the beta-galactosidase gene is no longer glucose repressed. LAC9 codes for a regulatory protein homologous to GAL4 which activates transcription in the presence of the inducer. Since the LAC9 product is also present in the repressed strain and binds to DNA in vitro, as shown by DNA footprinting, glucose repression cannot be caused by repression of LAC9 gene expression. Instead, our results demonstrate that glucose repression is mediated by the LAC9 gene product, and is separable from the ability of LAC9 to activate transcription.
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