ArticleBMC gastroenterology2014
The pathogenicity of Staphylococcus epidermidis on the intestinal organs of rats and mice: an experimental investigation.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Bioactive and Functional Properties of Protein Isolates and Hydrolysates from Edible Insects.Foods (Basel, Switzerland) · 2026Article
- Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.Cell reports. Medicine · 2026Article
- Gut Microbiota and Autism Spectrum Disorders: Neurodevelopmental, Behavioral, and Gastrointestinal Interactions.Nutrients · 2025Article
- Characterization and pathogenicity of multidrug-resistant coagulase-negative Staphylococci isolates in chickens.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Gut Microbial Disruption in Critically Ill Patients with COVID-19-Associated Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2022Article
- Lactobacillus rhamnosus and Staphylococcus epidermidis in gut microbiota: in vitro antimicrobial resistance.AMB Express · 2022Article
- The Effect of Tannin-Rich Witch Hazel on Growth of ProbioticAntibiotics (Basel, Switzerland) · 2022Article
- Genotypic and Phenotypic Characterization of FecalFrontiers in microbiology · 2020Article
- Recovery of aerobic and anaerobic bacteria from patients with acute appendicitis using blood culture bottlesBiomedica : revista del Instituto Nacional de Salud · 2019Observational
- Evaluation of the Sterility of Press'n Seal Cling Film for Use in Rodent Surgery.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their In Vivo Proinflammatory Effect.Infection and immunity · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus epidermidis is the most frequently isolated species of the coagulase negative staphylococci from human stool. However, it is not clear how its presence in the gut affects the cellular structures and functions of this organ. In this study therefore, the pathogenicity of strains of S. epidermidis which were isolated from the stool samples of apparently healthy children was investigated in mice and rats.
methodsThe albino mice (22-30 g) and albino rats (100-155 g) of both sexes were infected orally and intraperitoneally with graded doses of the bacteria and subjected to behavioral and histopathological examinations.
resultsAcute infection in these animals caused temporary behavioural changes as shown by restlessness and abdominal stretchings but did not result in death even at a dosage of 2 × 109 cfu/kg. Daily administration of the same dose for 14 days resulted in the death of 11 out of 21 (52.4%) mice. Histopathological examination of the affected organs showed congestions, aggregations and multinucleated hepatocytes in the liver, infiltration of the kidney tubule interstitial by chronic inflammatory cells, coagulative necrosis of the kidney, spleen, intestine and stomach cells as well as marked stroma fibrosis of the spleen. Coagulative necrosis of cells was the most frequently occurring pathological alteration. Lethality and pathological effects reflected the virulence factors expressed by the organism which are biofilm formation, haemagglutination properties and capsule production.
conclusionsThe results indicate that strains of S. epidermidis colonising the gut can cause serious pathological changes on certain organs such as kidney, liver, intestine, stomach and spleen which, depending on their severity, could be fatal.
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