ReviewCurrent opinion in genetics & development2014
Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology.
Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Short-chain fatty acids in the tumor microenvironment: from molecular mechanisms to cancer therapy.Theranostics · 2026Review
- Fantastic proteins and where to find them - histones, in the nucleus and beyond.Journal of cell science · 2024Review
- ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.Cell reports · 2024Article
- Metabolic sinkholes: Histones as methyl repositories.PLoS biology · 2023Article
- Article
- Nuclear oligo hashing improves differential analysis of single-cell RNA-seq.Nature communications · 2022Article
- Chromatin as a sensor of metabolic changes during early development.Frontiers in cell and developmental biology · 2022Review
- Reconsidering LINE-1's role in cancer: does LINE-1 function as a reporter detecting early cancer-associated epigenetic signatures?Evolution, medicine, and public health · 2021Review
- Massively multiplex chemical transcriptomics at single-cell resolution.Science (New York, N.Y.) · 2020Article
- Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer.Epigenetics & chromatin · 2019Article
- Epigenetic control in skin development, homeostasis and injury repair.Experimental dermatology · 2019Review
- Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism.Trends in endocrinology and metabolism: TEM · 2018Review
- Article
- Physical forces modulate cell differentiation and proliferation processes.Journal of cellular and molecular medicine · 2018Review
- Toward a Reasoned Classification of Diseases Using Physico-Chemical Based Phenotypes.Frontiers in physiology · 2018Article
- Article
- A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Undercover: gene control by metabolites and metabolic enzymes.Genes & development · 2016Review
- Article
- A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis.Cancer & metabolism · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cancer tissues with lower global levels of histone acetylation display significantly increased rate of tumor recurrence or cancer-related mortality. The function global regulation of histone acetylation serves for the cell or how lower levels of histone acetylation may contribute to a more aggressive cancer phenotype has been unclear. Chromatin and histone modifications are currently thought to regulate only DNA-based processes. However, recent findings have revealed a novel function for global histone acetylation in direct regulation of cellular physiology. I will discuss how chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.