Evidence map›Paper›PMID 25016379›Full record

ArticleGastroenterology report2014

Association between gastro-intestinal symptoms and menstruation in patients with ileal pouches.

Shishira Bharadwaj, Xian-Rui Wu, Matthew D Barber, Elaine Queener, Lesley Graff, Bo Shen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology report, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shishira BharadwajDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Xian-Rui WuDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Matthew D BarberDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Elaine QueenerDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Lesley GraffDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Bo ShenDepartments of Gastroenterology/Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Colorectal surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA and Obstetrics and Gynecology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA and Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada shenb@ccf.org.
Cleveland Clinic · USCleveland Foundation · USUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsGastro-intestinal (GI) symptoms are often experienced by healthy women during menstruation. An increased frequency of GI symptoms during menses has also been reported in women with irritable bowel syndrome or inflammatory bowel disease (IBD); however, IBD patients with restorative proctocolectomy and ileal pouch-anal anastomoses (IPAA) have not been studied. We aimed to examine the association between GI symptoms before and during menses in patients with IPAA, and to assess factors for exacerbation of GI symptoms in those patients.

methodsAdult women recorded in the Pouchitis Registry were invited to participate in a mailed survey. Participants reported on GI symptoms 1-5 days prior to- (pre-menses) and during the days of their menses in recent months. Demographic and clinical variables were obtained through the survey and chart review.

resultsOne hundred and twenty-eight (21.3%) out of 600 women with IPAA responded to the survey questionnaire. Forty-three (33.5%) were excluded for reasons including post-menopausal (n = 25), hysterectomy (n = 14) and use of contraceptives (n = 4). Abdominal pain (P = 0.001), diarrhea (P = 0.021), and urgency (P = 0.031) were more commonly reported during menses than pre-menses by the participants. Only a history of painful menses was significantly associated with increased GI symptoms during menses for patients with ileal pouch (odds ratio = 5.67; 95% confidence interval: 1.41-22.88; P = 0.015).

conclusionGI symptoms such as abdominal pain, diarrhea, and urgency are commonly associated with menses in patients with ileo-anal pouch. Painful menses may be associated with worsening of GI symptoms.

Indexed as

ileal pouch-anal anastomosisinflammatory bowel diseasemenstruationrestorative proctocolectomysymptomatology

Identifiers

PMID25016379
PMCPMC4124275
OpenAlexW2130577620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.