Trial reportOphthalmology2014
Low vision depression prevention trial in age-related macular degeneration: a randomized clinical trial.
Trial report in Ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00769015 (Low Vision Depression Prevention Trial for Age Related Macular Degeneration), which is not on this map. Cited by 54 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Vision Depression Prevention Trial for Age Related Macular Degeneration
Who cites it
54 citing papers in PubMed, 8 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Depression and Anxiety in Patients With Irreversible Vision Loss: Meta-Analysis and Systematic Review.International journal of psychiatry in medicine · 2026Pooled it
- Self-management interventions for quality of life in adults with visual impairment.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Prevention of depression in adults with long-term physical conditions.The Cochrane database of systematic reviews · 2021Pooled it
- Environmental and behavioural interventions for reducing physical activity limitation and preventing falls in older people with visual impairment.The Cochrane database of systematic reviews · 2020Pooled it
- Low vision rehabilitation for better quality of life in visually impaired adults.The Cochrane database of systematic reviews · 2020Pooled it
- The Prevalence of Depression and Depressive Symptoms among Eye Disease Patients: A Systematic Review and Meta-analysis.Scientific reports · 2017Pooled it
- Interventions Within the Scope of Occupational Therapy Practice to Improve Performance of Daily Activities for Older Adults With Low Vision: A Systematic Review.The American journal of occupational therapy : official publication of the American Occupational Therapy AssociationPooled it
- Improving Patient Reported Outcomes and Preventing Depression and Anxiety in Older Adults With Knee Osteoarthritis: Results of a Sequenced Multiple Assignment Randomized Trial (SMART) Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Trial
- Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial.BMC public health · 2017Trial
- Functional Outcomes of the Low Vision Depression Prevention Trial in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2017Trial
- Challenges and Solutions for Depression Prevention Research: Methodology for a Depression Prevention Trial for Older Adults with Knee Arthritis and Emotional Distress.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Trial
- Feasibility of Pairing Behavioral Activation With Exercise for Women With Type 2 Diabetes and Depression: The Get It Study Pilot Randomized Controlled Trial.Behavior therapy · 2016Trial
- The macular degeneration and aging study: Design and research protocol of a randomized trial for a psychosocial intervention with macular degeneration patients.Contemporary clinical trials · 2015Trial
- Factors mediating the effects of a depression intervention on functional disability in older African Americans.Journal of the American Geriatrics Society · 2014Trial
- A Within-Population Comparison of the Psychometric Properties and Clinical Feasibility of Visual Function Questionnaires in Low Vision.Translational vision science & technology · 2026Article
- Psychiatric disorders linked to visual impairment: A review of mental health challenges and interventions across age groups.World journal of psychiatry · 2026Review
- Allegiance and Treatment Quality as Moderators of the Comparative Effectiveness of Psychotherapy? A Systematic Review and Meta-Analysis of Studies Comparing Humanistic Psychotherapy to Other Psychotherapy Approaches.Clinical psychology in Europe · 2025Review
- Relationship between self-reported hearing and vision problems, cognitive decline, depressive symptoms, and life satisfaction in older adults: a retrospective observational study.BMC public health · 2024Observational
- Health Management Service Models for the Elderly with Visual Impairment: A Scoping Review.Journal of multidisciplinary healthcare · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTo compare the efficacy of behavior activation (BA) + low vision rehabilitation (LVR) with supportive therapy (ST) + LVR to prevent depressive disorders in patients with age-related macular degeneration (AMD).
designSingle-masked, attention-controlled, randomized, clinical trial with outcome assessment at 4 months.
participantsPatients with AMD and subsyndromal depressive symptoms attending retina practices (n = 188).
interventionsBefore randomization, all subjects had 2 outpatient LVR visits, and were then randomized to in-home BA+LVR or ST+LVR. Behavior activation is a structured behavioral treatment that aims to increase adaptive behaviors and achieve valued goals. Supportive therapy is a nondirective, psychological treatment that provides emotional support and controls for attention.
main outcome measuresThe Diagnostic and Statistical Manual IV defined depressive disorder based on the Patient Health Questionnaire-9 (primary outcome), Activities Inventory, National Eye Institute Vision Function Questionnaire-25 plus Supplement (NEI-VFQ), and NEI-VFQ quality of life (secondary outcomes).
resultsAt 4 months, 11 BA+LVR subjects (12.6%) and 18 ST+LVR subjects (23.4%) developed a depressive disorder (relative risk [RR], 0.54; 95% CI, 0.27-1.06; P = 0.067). In planned adjusted analyses the RR was 0.51 (95% CI, 0.27-0.98; P = 0.04). A mediational analysis suggested that BA+LVR prevented depression to the extent that it enabled subjects to remain socially engaged. In addition, BA+LVR was associated with greater improvements in functional vision than ST+LVR, although there was no significant between-group difference. There was no significant change or between-group difference in quality of life.
conclusionsAn integrated mental health and low vision intervention halved the incidence of depressive disorders relative to standard outpatient LVR in patients with AMD. As the population ages, the number of persons with AMD and the adverse effects of comorbid depression will increase. Promoting interactions between ophthalmology, optometry, rehabilitation, psychiatry, and behavioral psychology may prevent depression in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.