ArticleCell calcium2014
Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels.
Article in Cell calcium, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Dissociation of inositol 1,4,5-trisphosphate from IPThe Journal of biological chemistry · 2023Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data.Nature communications · 2021Article
- Quantal CaCell reports · 2021Article
- IPeLife · 2020Article
- Noise analysis of cytosolic calcium image data.Cell calcium · 2020Article
- Spatial Coupling Tunes NMDA Receptor Responses via CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spatial-temporal patterning of CaSeminars in cell & developmental biology · 2019Review
- All three IPScience signaling · 2018Article
- SICT: automated detection and supervised inspection of fast CaScientific reports · 2018Article
- Pulsed infrared releases CaJournal of neurophysiology · 2018Article
- Dynamic CaCell calcium · 2018Article
- Endogenous signalling pathways and caged IPJournal of cell science · 2017Article
- Clusters of calcium release channels harness the Ising phase transition to confine their elementary intracellular signals.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The calcium-cancer signalling nexus.Nature reviews. Cancer · 2017Review
- Calcitox-aging counterbalanced by endogenous farnesol-like sesquiterpenoids: An undervalued evolutionarily ancient key signaling pathway.Communicative & integrative biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Calcium puffs are localized Ca(2+) signals mediated by Ca(2+) release from the endoplasmic reticulum (ER) through clusters of inositol trisphosphate receptor (IP3R) channels. The recruitment of IP3R channels during puffs depends on Ca(2+)-induced Ca(2+) release, a regenerative process that must be terminated to maintain control of cell signaling and prevent Ca(2+) cytotoxicity. Here, we studied puff termination using total internal reflection microscopy to resolve the gating of individual IP3R channels during puffs in intact SH-SY5Y neuroblastoma cells. We find that the kinetics of IP3R channel closing differ from that expected for independent, stochastic gating, in that multiple channels tend to remain open together longer than predicted from their individual open lifetimes and then close in near-synchrony. This behavior cannot readily be explained by previously proposed termination mechanisms, including Ca(2+)-inhibition of IP3Rs and local depletion of Ca(2+) in the ER lumen. Instead, we postulate that the gating of closely adjacent IP3Rs is coupled, possibly via allosteric interactions, suggesting an important mechanism to ensure robust puff termination in addition to Ca(2+)-inactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.