SynthesisRadiation oncology (London, England)2014
Stereotactic radiosurgery (SRS) for brain metastases: a systematic review.
Synthesis in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03285932 (Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Post-operative Whole-brain Radiotherapy), which is not on this map. Cited by 89 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Post-operative Whole-brain Radiotherapy
Who cites it
89 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Survival Outcome of Surgical Resection vs. Radiotherapy in Brain Metastasis From Colorectal Cancer: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Brain metastasis detection using machine learning: a systematic review and meta-analysis.Neuro-oncology · 2021Pooled it
- The role of simulation in neurosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Pooled it
- Radiosurgery with flattening-filter-free techniques in the treatment of brain metastases : Plan comparison and early clinical evaluation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016Trial
- Dose selection and clinical decision-making after Gamma Knife surgery for large brain metastases: implications for early identification of true progression.Journal of neuro-oncology · 2026Observational
- Stereotactic Radiosurgery for Thalamic Brain Metastases: A Retrospective Analysis and Literature Review.Neurosurgery practice · 2026Article
- A multi-institutional survey on radiosurgery for multiple brain metastases in Latin America.Physical and engineering sciences in medicine · 2026Article
- Evaluation of a Monte Carlo-based independent dose calculation system for brain stereotactic radiotherapy using a robotic radiosurgery system.Radiological physics and technology · 2026Article
- Prognostic Analysis of Lung Cancer With Brain Metastases in Elderly Patients: A Multicenter Retrospective Study.Aging medicine (Milton (N.S.W)) · 2025Article
- Review
- HyperArc Automated Stereotactic Radiosurgery Planning Enables Accurate a Priori Fractionation Scheme Selection via Adherence to HyTEC Toxicity Thresholds.Advances in radiation oncology · 2025Article
- AI differentiates radionecrosis from true progression in brain metastasis upon stereotactic radiosurgery: Analysis of 124 histologically assessed lesions.Neuro-oncology · 2025Article
- Auxiliary Value of [Cancers · 2025Article
- Classifying Stereotactic Radiosurgery Patients by Primary Diagnosis Using Natural Language Processing of Clinical Notes.JCO clinical cancer informatics · 2025Article
- Temporal evolution of MRI findings and survival outcomes in patients with brain metastases after stereotactic radiosurgery.BMC medical imaging · 2025Article
- Streamlit Application and Deep Learning Model for Brain Metastasis Monitoring After Gamma Knife Treatment.Biomedicines · 2025Article
- Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study.Frontiers in immunology · 2025Article
- Article
- Long-Term Imaging Follow-up of Radiation Necrosis After Stereotactic Radiosurgery: A Case Report and Lessons Learned.Advances in radiation oncology · 2024Article
- Independent Monte Carlo dose calculation identifies single isocenter multi-target radiosurgery targets most likely to fail pre-treatment measurement.Journal of applied clinical medical physics · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many patients with brain metastases, the primary therapeutic aim is symptom palliation and maintenance of neurologic function, but in a subgroup, long-term survival is possible. Local control in the brain, and absent or controlled extracranial sites of disease are prerequisites for favorable survival. Stereotactic radiosurgery (SRS) is a focal, highly precise treatment option with a long track record. Its clinical development and implementation by several pioneering institutions eventually rendered possible cooperative group randomized trials. A systematic review of those studies and other landmark studies was undertaken. Most clinicians are aware of the potential benefits of SRS such as a short treatment time, a high probability of treated-lesion control and, when adhering to typical dose/volume recommendations, a low normal tissue complication probability. However, SRS as sole first-line treatment carries a risk of failure in non-treated brain regions, which has resulted in controversy around when to add whole-brain radiotherapy (WBRT). SRS might also be prescribed as salvage treatment in patients relapsing despite previous SRS and/or WBRT. An optimal balance between intracranial control and side effects requires continued research efforts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.