Evidence map›Paper›PMID 25016248›Full record

ArticleDevelopmental cognitive neuroscience2014

Motor fMRI and cortical grey matter volume in adults born very preterm.

E J Lawrence, S Froudist-Walsh, R Neilan, K W Nam, V Giampietro, P McGuire, R M Murray, C Nosarti

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In one paragraph

Article in Developmental cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Cerebellar Development and the Burden of Prematurity.Cerebellum (London, England) · 2025
    Review
  2. Article
  3. Advances in functional and diffusion neuroimaging research into the long-term consequences of very preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Review
  4. Review
  5. Glutamate Transport and Preterm Brain Injury.Frontiers in physiology · 2019
    Review
  6. Article
  7. Social brain circuitry and social cognition in infants born preterm.Journal of neurodevelopmental disorders · 2017
    Review
  8. Article
  9. Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E J LawrenceDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: emma.lawrence@kcl.ac.uk.
S Froudist-WalshDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: sean.froudist_walsh@kcl.ac.uk.
R NeilanDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: rachel_neilan@hotmail.com.
K W NamDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: kie_woo.nam@kcl.ac.uk.
V GiampietroDepartment of Neuroimaging, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: vincent.giampietro@kcl.ac.uk.
P McGuireDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: philip.p.mcguire@kcl.ac.uk.
R M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: robin.murray@kcl.ac.uk.
C NosartiDepartment of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK; Centre for the Developing Brain, King's Health Partners, King's College London, First Floor, South Wing, St Thomas' Hospital, London SE1 7EH, UK. Electronic address: chiara.nosarti@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary aim of this study was to investigate the functional neuroanatomy of motor planning, initiation and execution in a cohort of young adults (mean age 20 years) who were born very preterm (VPT; <33 weeks of gestation), as these individuals are at increased risk of experiencing neuromotor difficulties compared to controls. A cued motor task was presented to 20 right-handed VPT individuals and 20 controls within a functional magnetic resonance imaging (fMRI) paradigm. Whole-brain grey matter volume was also quantified and associations with functional data were examined. Despite comparable task performance, fMRI results showed that the VPT group displayed greater brain activation compared to controls in a region comprising the right cerebellum and the lingual, parahippocampal and middle temporal gyri. The VPT group also displayed decreased grey matter volume in the right superior frontal/premotor cortex and left middle temporal gyri. Grey matter volume in the premotor and middle temporal clusters was significantly negatively correlated with BOLD activation in the cerebellum. Overall, these data suggest that preterm birth is associated with functional neuronal differences that persist into adulthood, which are likely to reflect neural reorganisation following early brain injury.

Indexed as

Gestational AgeBrain MappingCase-Control StudiesCerebellumCognitionFemaleGray MatterHumansInfant, Extremely PrematureIntelligenceIntelligence TestsMagnetic Resonance ImagingMaleMotor CortexMotor SkillsPregnancyAdultCognitivefMRIMotorNeurodevelopmentPreterm

Identifiers

PMID25016248
PMCPMC4256062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.