Evidence map›Paper›PMID 25016200›Full record

ArticleBrain, behavior, and immunity2015

Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress.

Keely A Muscatell, Katarina Dedovic, George M Slavich, Michael R Jarcho, Elizabeth C Breen, Julienne E Bower, Michael R Irwin, Naomi I Eisenberger

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 143 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 8 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05654441 phase4completednot on this mapstarted 2022, after this paper: background citation

Low-grade Inflammatory Challenge and Social Behavior

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2023Enrolled104ConditionsPsychology, Social, Inflammation, Defeat, Social, Interaction, SocialArmsInfluenza vaccine, Placebo
NCT06263452 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2026Enrolled120ConditionsCardiovascular DiseaseArmsPropranolol, Placebo
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 8 syntheses or guidelines pooled it, 231 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Stress-related genetic factors modify the effect of socioeconomic status on cardiovascular risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  20. The Role of Long Non-Coding RNA in Anxiety Disorders: A Literature Review.International journal of molecular sciences · 2025
    Review

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Keely A MuscatellRobert Wood Johnson Foundation Health and Society Scholars Program, University of California, San Francisco and University of California, Berkeley, San Francisco, CA, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Katarina DedovicDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry, Research Centre of the Douglas Mental Health University Institute, Montreal, Quebec, Canada.
George M SlavichDepartment of Psychiatry & Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Michael R JarchoDepartment of Psychiatry & Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Neuroscience, Loras College, Dubuque, IA, USA.
Elizabeth C BreenDepartment of Psychiatry & Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Julienne E BowerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry & Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Michael R IrwinDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry & Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: neisenbe@ucla.edu.
University of California, Los Angeles · USDouglas Mental Health University Institute · CALoras College · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUBEN, DAVID B. · 2006 to 2017
$9.8M
PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
CIHRNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NIA NIH HHS AG028748NIA NIH HHS P30 AG028748NIMH NIH HHS K08 MH103443NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

Psychological stress is implicated in the etiology of many common chronic diseases and mental health disorders. Recent research suggests that inflammation may be a key biological mediator linking stress and health. Nevertheless, the neurocognitive pathways underlying stress-related increases in inflammatory activity are largely unknown. The present study thus examined associations between neural and inflammatory responses to an acute laboratory-based social stressor. Healthy female participants (n=31) were exposed to a brief episode of stress while they underwent an fMRI scan. Blood samples were taken before and after the stressor, and plasma was assayed for markers of inflammatory activity. Exposure to the stressor was associated with significant increases in feelings of social evaluation and rejection, and with increases in levels of inflammation. Analyses linking the neural and inflammatory data revealed that heightened neural activity in the amygdala in response to the stressor was associated with greater increases in inflammation. Functional connectivity analyses indicated that individuals who showed stronger coupling between the amygdala and the dorsomedial prefrontal cortex (DMPFC) also showed a heightened inflammatory response to the stressor. Interestingly, activity in a different set of neural regions was related to increases in feelings of social rejection. These data show that greater amygdala activity in response to a stressor, as well as tighter coupling between the amygdala and the DMPFC, are associated with greater increases in inflammatory activity. Results from this study begin to identify neural mechanisms that might link stress with increased risk for inflammation-related disorders such as cardiovascular disease and depression.

Indexed as

AdolescentAmygdalaBiomarkersEmotionsFemaleHumansInflammationInterleukin-6Magnetic Resonance ImagingNeural PathwaysPrefrontal CortexStress, PsychologicalTumor Necrosis Factor-alphaYoung AdultBiomarkersInterleukin-6Tumor Necrosis Factor-alphaAmygdalafMRIIL-6InflammationMedial prefrontal cortexNeuroimagingSocial rejectionSocial stressStress

Identifiers

PMID25016200
PMCPMC4368432
OpenAlexW1968731032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.