SynthesisBrain and language2014
The role of the insula in speech and language processing.
Synthesis in Brain and language, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
109 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Brain activation patterns of figurative language comprehension in individuals with autism spectrum disorder: an activation likelihood estimation meta-analysis.Frontiers in neuroscience · 2026Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis.Journal of autism and developmental disorders · 2021Pooled it
- Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review.Neurosurgical review · 2021Pooled it
- Effects of Linguistic Distance on Second Language Brain Activations in Bilinguals: An Exploratory Coordinate-Based Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis.Brain imaging and behavior · 2020Pooled it
- Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies.Human brain mapping · 2019Pooled it
- Neural representation of word categories is distinct in the temporal lobe: An activation likelihood analysis.Human brain mapping · 2018Pooled it
- Brain areas associated with numbers and calculations in children: Meta-analyses of fMRI studies.Developmental cognitive neuroscience · 2018Pooled it
- A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping.Neuroradiology · 2017Pooled it
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- Intervention-specific patterns of cortical function plasticity during auditory encoding in people with schizophrenia.Schizophrenia research · 2020Trial
- Article
- Explicitly nonlinear fMRI networks reveal hidden trajectories of infant brain development.bioRxiv : the preprint server for biology · 2026Article
- Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026Article
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Listening Without the Noise: Near-Silent Looping Star fMRI Reveals Neural Processing of Degraded Speech.Human brain mapping · 2026Article
- Effective connectivity of the insula as measured by cortico-cortical evoked potentials.medRxiv : the preprint server for health sciences · 2026Article
- Strengthening the Aging Brain: Functional Connectivity Changes After a Language-Based Cognitive Program.Brain sciences · 2025Article
- Children with lower language skill engage additional brain mechanisms in both hemispheres during sentence comprehension.Research square · 2025Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Lesion and neuroimaging studies indicate that the insula mediates motor aspects of speech production, specifically, articulatory control. Although it has direct connections to Broca's area, the canonical speech production region, the insula is also broadly connected with other speech and language centres, and may play a role in coordinating higher-order cognitive aspects of speech and language production. The extent of the insula's involvement in speech and language processing was assessed using the Activation Likelihood Estimation (ALE) method. Meta-analyses of 42 fMRI studies with healthy adults were performed, comparing insula activation during performance of language (expressive and receptive) and speech (production and perception) tasks. Both tasks activated bilateral anterior insulae. However, speech perception tasks preferentially activated the left dorsal mid-insula, whereas expressive language tasks activated left ventral mid-insula. Results suggest distinct regions of the mid-insula play different roles in speech and language processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.