ArticleReproductive sciences (Thousand Oaks, Calif.)2015
Stress management affects outcomes in the pathophysiology of an endometriosis model.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models.Molecular human reproduction · 2025Pooled it
- Predictive markers of endometriosis: a future perspective.Archives of gynecology and obstetrics · 2026Review
- Causal Association Between Sleep Traits and Endometriosis: A Mendelian Randomization Study.International journal of women's health · 2026Article
- Metabolomics for the identification of biomarkers in endometriosis.Archives of gynecology and obstetrics · 2024Review
- Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming.International journal of molecular sciences · 2023Article
- Efficacy of an environmental enrichment intervention for endometriosis: a pilot study.Frontiers in psychology · 2023Article
- Feasibility and acceptability of an adapted environmental enrichment intervention for endometriosis: A pilot study.Frontiers in global women's health · 2022Article
- Metabolomics in endometriosis: challenges and perspectives for future studies.Reproduction & fertility · 2021Review
- "Es que tú eres una changa": stigma experiences among Latina women living with endometriosis.Journal of psychosomatic obstetrics and gynaecology · 2021Article
- Voluntary Wheel Running Reduces Vesicle Development in an Endometriosis Animal Model Through Modulation of Immune Parameters.Frontiers in reproductive health · 2021Article
- Hypothalamic-Pituitary-Adrenal Axis Responses in Women with Endometriosis-Related Chronic Pelvic Pain.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario.Reproductive sciences (Thousand Oaks, Calif.) · 2020Review
- Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Early maternal separation accelerates the progression of endometriosis in adult mice.Reproductive biology and endocrinology : RB&E · 2020Article
- Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis.PloS one · 2020Article
- Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis.PloS one · 2018Article
- Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown detrimental effects of stress in an animal model of endometriosis. We now investigated whether the ability to control stress can affect disease parameters. Endometriosis was surgically induced in female Sprague-Dawley rats before exposing animals to a controllable (submerged platform) or uncontrollable (no platform) swim stress protocol. Corticosterone levels and fecal pellet numbers were measured as an indicator of stress. Uncontrollable stress increased the number and size of the endometriotic cysts. Rats receiving uncontrollable stress had higher anxiety than those exposed to controllable stress or no stress and higher corticosterone levels. Uncontrollable stressed rats had more colonic damage and uterine cell infiltration compared to no stress, while controllable stress rats showed less of an effect. Uncontrollable stress also increased both colonic and uterine motility. In summary, the level of stress controllability appears to modulate the behavior and pathophysiology of endometriosis and offers evidence for evaluating therapeutic interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.