Evidence map›Paper›PMID 25015869›Full record

ArticleAmerican journal of clinical pathology2014

Massive dissemination from spinal cord gangliogliomas negative for BRAF V600E: report of two rare adult cases.

Seth C Lummus, Dara L Aisner, Sharon B Sams, Nicholas K Foreman, Kevin O Lillehei, B K Kleinschmidt-DeMasters

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Practical aspects regarding the histopathological grading and anaplastic transformation of gangliogliomas - a literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Seth C LummusFrom the Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO;
Dara L AisnerFrom the Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO;
Sharon B SamsFrom the Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO;
Nicholas K ForemanDepartments of Pathology and Neuro-Oncology, Children's Hospital Colorado, Aurora, CO;
Kevin O LilleheiDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO; and.
B K Kleinschmidt-DeMastersFrom the Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO; and Department of Neurology, Anschutz Medical Campus, University of Colorado at Denver, Aurora, CO. bk.demasters@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USChildren's Hospital Colorado · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046934NCI NIH HHS P30CA046934
6 · The paper itself

Abstract

objectivesMetastatic leptomeningeal spread from spinal cord gangliogliomas (GGs) is exceedingly rare.

methodsTwo adult women, aged 27 and 51 years, died of massive disseminations of cervicothoracic GGs 4 and 6 years, respectively, after initial diagnoses; full autopsies were performed. BRAF status was assessed by VE1 immunohistochemistry (IHC), Sanger sequencing, and a single-nucleotide base extension assay (SNaPshot, Applied Biosystems, Princeton, NJ).

resultsThe 27-year-old underwent two biopsies, chemotherapy, radiation, and ventriculoperitoneal shunt placement; she developed craniospinal and peritoneal dissemination. Autopsy confirmed shunt-mediated peritoneal metastases, microscopic bone marrow involvement, and profuse spinal and supratentorial leptomeningeal and parenchymal spread. The 51-year-old underwent two resections, radiation, and chemotherapy and developed pancytopenia with biopsy-proven bony metastases 15 months before death. Autopsy demonstrated leptomeningeal, subpial, and subependymal metastases. The tumors in both primary and metastatic sites were BRAF negative by VE1 IHC and two different mutational analyses. This compared with negative BRAF results for an additional four nonmetastatic adult nonsupratentorial GGs and in our study.

conclusionsWe document two rare cases of massively metastatic spinal cord GGs in adult patients who were negative for BRAF V600E mutations via multiple methods.

Indexed as

AdultBiomarkers, TumorDNA Mutational AnalysisFemaleGangliogliomaHumansMiddle AgedMutationProto-Oncogene Proteins B-rafSpinal Cord NeoplasmsBiomarkers, TumorProto-Oncogene Proteins B-rafBone marrowBRAF V600EGangliogliomaIntramedullaryMetastasisSpinal cordVE1

Identifiers

PMID25015869
PMCPMC4616006
OpenAlexW2107560345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.