ArticleAmerican journal of clinical pathology2014
Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
Article in American journal of clinical pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal.Journal of medical virology · 2019Trial
- Hidden in plain sight: the impact of human rhinovirus infection in adults.Respiratory research · 2025Review
- Clinical characteristics, outcomes, and subtype diversity in hospitalized human rhinovirus (HRV) patients.PloS one · 2025Article
- Article
- Different Clinical Presentations of Human Rhinovirus Species Infection in Children and Adults in Mexico.Open forum infectious diseases · 2022Article
- Molecular epidemiology and clinical characterization of human rhinoviruses circulating in Shanghai, 2012-2020.Archives of virology · 2022Article
- Age-Specific Etiology of Severe Acute Respiratory Infections and Influenza Vaccine Effectivity in Prevention of Hospitalization in Russia, 2018-2019 Season.Journal of epidemiology and global health · 2021Article
- Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance.Viruses · 2021Article
- RV-C infections result in greater clinical symptoms and epithelial responses compared to RV-A infections in patients with CRS.Allergy · 2020Article
- Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults.Infectious disease clinics of North America · 2017Review
- Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults.Respiratory medicine · 2017Observational
- The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma.Therapeutic advances in respiratory disease · 2016Review
- Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults.The Journal of allergy and clinical immunology · 2016Article
- Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
- Genetic diversity of human rhinoviruses in Cambodia during a three-year period reveals novel genetic types.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults.
methodsSeventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the VP4 gene and 5' terminus of the VP2 gene. The clinical features and severity of illness associated with the different RV species were compared.
resultsPhylogenetic analysis identified three distinct clusters as RV-A (54%), B (11%), or C (35%) species. In an unadjusted model, patients with RV-B infection were significantly more likely to have the composite outcome variable of death or intensive care unit admission (P=.03), but this effect diminished when controlling for patient sex. A logistic model of the relationship between RV species and adverse outcomes produced nonsignificant odds ratios when controlling for patient sex.
conclusionsInfection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders.
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Registered trials
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