Evidence map›Paper›PMID 25015688›Full record

ArticleDrug and alcohol dependence2014

Anxiety sensitivity as an amplifier of subjective and behavioral tobacco abstinence effects.

Michael J Zvolensky, Samantha G Farris, Casey R Guillot, Adam M Leventhal

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  7. Associations of Trait Psychomotor Restlessness and Agitation With Tobacco Withdrawal Symptoms in a Nonclinical Sample of Adults Who Smoke Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
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  9. Tobacco Withdrawal Symptoms Before and After Nicotine Deprivation in Veteran Smokers with Posttraumatic Stress Disorder and with Major Depressive Disorder.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael J ZvolenskyUniversity of Houston, Department of Psychology, Fred J. Heyne Building, Suite 104, Houston, TX 77204, USA; The University of Texas MD Anderson Cancer Center, Department of Behavioral Science, 1155 Pressler Street, Houston, TX 77030, USA. Electronic address: mjzvolen@central.uh.edu.
Samantha G FarrisThe University of Texas MD Anderson Cancer Center, Department of Behavioral Science, 1155 Pressler Street, Houston, TX 77030, USA.
Casey R GuillotUniversity of Southern California Keck School of Medicine, Department of Preventive Medicine, 2250 Alcazar, St, CSC 240, Los Angeles, CA 90033, USA.
Adam M LeventhalUniversity of Southern California Keck School of Medicine, Department of Preventive Medicine, 2250 Alcazar, St, CSC 240, Los Angeles, CA 90033, USA; University of Southern California, Department of Psychology, 2250 Alcazar, St, CSC 240, Los Angeles, CA 90033, USA.

Funding

R25 SUPPLEMENT IN GENETIC EPIDEMIOLOGY EDUCATIONR25CA057730 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE · 1992 to 2016
$18.6M
Mechanisms Linking Anhedonia and Tobacco AddictionR01DA026831 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEVENTHAL, ADAM MATTHEW · 2009 to 2012
$1.1M
Affective and Genetic Correlates of Amphetamine ResponseK08DA025041 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEVENTHAL, ADAM MATTHEW · 2009 to 2013
$773k
Panic-Relevant Sensations and Smoking MotivationF31DA035564 · NIDA · UNIVERSITY OF HOUSTON · PI FARRIS, SAMANTHA GWEN · 2013 to 2015
$101k
NCI NIH HHS R25 CA057730NIDA NIH HHS F31 DA035564NIDA NIH HHS F31-DA035564NIDA NIH HHS K08 DA025041NIDA NIH HHS K08-DA025041NIDA NIH HHS R01 DA026831NIDA NIH HHS R01-DA026831
6 · The paper itself

Abstract

backgroundAnxiety sensitivity, a transdiagnostic cognitive vulnerability factor described as an amplifier of negative emotional states, is implicated in the maintenance of cigarette smoking and cessation difficulties. The current study aimed to examine the role of anxiety sensitivity in predicting abstinence-induced changes in nicotine withdrawal, smoking urges and smoking behavior during an experimental relapse analogue task (RAT).

methodParticipants were 258 non-treatment seeking smokers (M [SD] age=44.0 [10.73]; 69.8% male). Participants attended two counterbalanced experimental sessions including smoking deprivation (16 h of smoking abstinence) and smoking as usual. The Minnesota Nicotine Withdrawal Scale (MNWS) and Brief Questionnaire of Smoking Urges (QSU) were completed at each session in addition to the RAT. Hierarchical regressions were conducted to examine the predictive impact of anxiety sensitivity on withdrawal and urges during smoking deprivation. Follow-up mediational analyses were conducted to examine whether abstinence-induced withdrawal and urges mediated responding during the RAT.

resultsAnxiety sensitivity amplified the effects of experimentally manipulated acute abstinence on subjective nicotine withdrawal symptoms and smoking urges. Additionally, higher levels of anxiety sensitivity indirectly predicted shorter latency to smoking initiation after deprivation during the RAT through the effects of greater abstinence-induced nicotine withdrawal and smoking urges. Anxiety sensitivity was unrelated to increased smoking during the RAT, although this may be partially attributed to the type of laboratory assessment employed.

conclusionsElevated anxiety sensitivity appears to impact initiation of smoking after nicotine deprivation through the effects of abstinence-induced withdrawal and smoking urges.

Indexed as

AdultAnxietyFemaleHumansMaleMiddle AgedNicotianaSmokingSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderAnxiety sensitivityNicotine withdrawalRelapse analogue taskSmoking urges

Identifiers

PMID25015688
PMCPMC4127105

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.