ArticleStem cells translational medicine2014
Laminin-111 improves skeletal muscle stem cell quantity and function following eccentric exercise.
Article in Stem cells translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies.Muscles (Basel, Switzerland) · 2025Review
- Continuous protein-density gradients: A new approach to correlate physical cues with cell response.PNAS nexus · 2024Article
- Extracellular Matrix and the Production of Cultured Meat.Foods (Basel, Switzerland) · 2021Review
- Co-delivery of fibrin-laminin hydrogel with mesenchymal stem cell spheroids supports skeletal muscle regeneration following trauma.Journal of tissue engineering and regenerative medicine · 2021Article
- Biomimetic sponges improve muscle structure and function following volumetric muscle loss.Journal of biomedical materials research. Part A · 2021Article
- Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Extracellular matrix: an important regulator of cell functions and skeletal muscle development.Cell & bioscience · 2021Review
- Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophy.Human molecular genetics · 2019Article
- The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury.Tissue engineering. Part A · 2019Article
- Regulation of Myogenic Activity by Substrate and Electrical StimulationBioResearch open access · 2019Article
- Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro.Stem cell reports · 2018Article
- Article
- Sexual dimorphism in laryngeal muscle fibers and ultrasonic vocalizations in the adult rat.The Laryngoscope · 2017Article
- Engineered matrices for skeletal muscle satellite cell engraftment and function.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3.Skeletal muscle · 2017Article
- Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160.Molecular therapy. Nucleic acids · 2017Article
- Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- In vivo evaluation of adipose- and muscle-derived stem cells as a treatment for nonhealing diabetic wounds using multimodal microscopy.Journal of biomedical optics · 2016Article
- Understanding the Role of ECM Protein Composition and Geometric Micropatterning for Engineering Human Skeletal Muscle.Annals of biomedical engineering · 2016Article
- Human Placenta Laminin-111 as a Multifunctional Protein for Tissue Engineering and Regenerative Medicine.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laminin-111 (α1, β1, γ1; LM-111) is an important component of the extracellular matrix that is required for formation of skeletal muscle during embryonic development. Recent studies suggest that LM-111 supplementation can enhance satellite cell proliferation and muscle function in mouse models of muscular dystrophy. The purpose of this study was to determine the extent to which LM-111 can alter satellite and nonsatellite stem cell quantity following eccentric exercise-induced damage in young adult, healthy mice. One week following injection of LM-111 or saline, mice either remained sedentary or were subjected to a single bout of downhill running (EX). While one muscle was preserved for evaluation of satellite cell number, the other muscle was processed for isolation of mesenchymal stem cells (MSCs; Sca-1+CD45-) via FACS at 24 hours postexercise. Satellite cell number was approximately twofold higher in LM-111/EX compared with all other groups (p<.05), and the number of satellite cells expressing the proliferation marker Ki67 was 50% to threefold higher in LM-111/EX compared with all other groups (p<.05). LM-111 also increased the quantity of embryonic myosin heavy chain-positive (eMHC+) fibers in young mice after eccentric exercise (p<.05). Although MSC percentage and number were not altered, MSC proinflammatory gene expression was decreased, and hepatocyte growth factor gene expression was increased in the presence of LM-111 (p<.05). Together, these data suggest that LM-111 supplementation provides a viable solution for increasing skeletal muscle stem cell number and/or function, ultimately allowing for improvements in the regenerative response to eccentric exercise.
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