ArticleThe Journal of pediatrics2014
Cardiac autonomic dysfunction and arterial stiffness among children and adolescents with attention deficit hyperactivity disorder treated with stimulants.
Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Is methylphenidate truly cardiac-safe? Insight from biventricular speckle tracking echocardiography in pediatric patients with attention deficit hyperactivity disorder.European journal of pediatrics · 2026Article
- Early-life adversity before age 5 is associated with reduced cardiometabolic health characterized by increased arterial stiffness and inflammation in adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Use of methylphenidate and the risk of cardiovascular diseases in children and adolescents with a family history of heart diseases and congenital heart diseases: A self-controlled case series study.European child & adolescent psychiatry · 2026Article
- Autonomic characterization in adults with attention deficit hyperactivity disorder assessed by heart rate variability measurement during a three-behavioral state paradigm: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Association between methylphenidate use and long-term cardiovascular risk in paediatric patients with attention deficit and hyperactivity disorder.BMJ paediatrics open · 2024Article
- Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age.Journal of the American Heart Association · 2024Article
- Central serous chorioretinopathy associated with Adderall (dextroamphetamine-amphetamine) and topical steroid use.American journal of ophthalmology case reports · 2022Article
- Aversion to Off-label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard.The Journal of clinical endocrinology and metabolism · 2021Article
- Integrating anthropometric and cardiometabolic health methods in stress, early experiences, and development (SEED) science.Developmental psychobiology · 2021Review
- Coherence Between Feelings and Heart Rate: Links to Early Adversity and Responses to Stress.Affective science · 2021Article
- Evaluation and Management of Elevated Blood Pressure in Children and Adolescents with Attention Deficit Hyperactivity Disorder.Current hypertension reports · 2019Review
- Early Life Adversity with Height Stunting Is Associated with Cardiometabolic Risk in Adolescents Independent of Body Mass Index.The Journal of pediatrics · 2018Article
- Brief Report: Physical Activity, Body Mass Index and Arterial Stiffness in Children with Autism Spectrum Disorder: Preliminary Findings.Journal of autism and developmental disorders · 2018Article
- Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS).European child & adolescent psychiatry · 2017Article
- Impact of Stimulant Medication Use on Heart Rate and Systolic Blood Pressure During Submaximal Exercise Treadmill Testing in Adolescents.Journal of child and adolescent psychopharmacology · 2016Article
- Heart Rate Recovery and Systolic Blood Pressure Recovery After Maximal Exercise in Prevalent Users of Stimulant Medications.Journal of clinical psychopharmacology · 2016Article
- Impaired cardiac autonomic nervous system function is associated with pediatric hypertension independent of adiposity.Pediatric research · 2016Article
- Impact of Health Status and Lifestyle Modifications on Vascular Structure and Function in Children and Adolescents.American journal of lifestyle medicineReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare markers of cardiovascular health in youth diagnosed with attention deficit hyperactivity disorder (ADHD) by the use of stimulant medication with healthy controls. STUDY
designChildren and adolescents (n = 85; mean age 11.2 ± 2.8 years; 66 boys) diagnosed with ADHD using a stimulant and 53 siblings without ADHD (mean age 11.1 ± 3.8 years; 28 boys) were included in this cross-sectional study. Measured variables included blood pressure, heart rate (HR), HR variability: SD of the RR interval and low frequency to high frequency ratio, carotid-radial pulse wave velocity, carotid artery augmentation index (AIx), radial artery AIx, brachial artery flow-mediated dilation, and digital reactive hyperemic index.
resultsCompared with control patients, participants with ADHD had greater resting systolic blood pressure (3.9 mm Hg, 95% CI [1.2-6.7], P = .005), diastolic blood pressure (5.5 mm Hg, 95% CI [3.2-7.8], P < .001), HR (9.2 beats/min, 95% CI [6.0-12.3], P < .001), low frequency to high frequency ratio (0.55, 95% CI [0.22-0.89], P = .001), carotid AIx (7.2%, 95% CI [1.9-12.5], P = .008), and pulse wave velocity (0.36 m/s, 95% CI [-0.05, 0.78], P = .089), and lower SD of the RR interval (-33.7 milliseconds, 95% CI [-46.1, -21.3], P < .001). Neither flow-mediated dilation nor reactive hyperemic index was significantly different.
conclusionsChildren and adolescents being treated with a stimulant medication for ADHD exhibited signs of altered cardiac autonomic function, characterized by increased sympathetic tone, and showed evidence of arterial stiffening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.