ArticleOncotarget2014
Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- RBP2 promotes gastric cancer cell migration by acting as a competitive endogenous RNA to upregulate SOX4 via sponging miR-212-3p.Scientific reports · 2025Article
- JMJD family proteins in cancer and inflammation.Signal transduction and targeted therapy · 2022Review
- The emerging role of KDM5A in human cancer.Journal of hematology & oncology · 2021Review
- Mechanisms of JARID1B Up-Regulation and Its Role inFrontiers in oncology · 2021Article
- Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1.JCI insight · 2020Article
- Histone demethylase PHF8 promotes progression and metastasis of gastric cancer.American journal of cancer research · 2017Article
- Epigenetic roles in the malignant transformation of gastric mucosal cells.Cellular and molecular life sciences : CMLS · 2016Review
- Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway.Molecular oncology · 2016Article
- Molecular mechanisms of gastric cancer initiation and progression by Helicobacter pylori.Current opinion in infectious diseases · 2016Review
- Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia.World journal of gastroenterology · 2016Article
- Article
- Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma.Oncotarget · 2015Article
- MicroRNAs and lncRNAs in senescence: A re-view.IUBMB life · 2015Review
- Down-regulation of miR-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric epithelial cell malignant transformation induced by Helicobactor Pylori contributes to tumor development, but the underlying mechanisms for this remain unclear. Here we demonstrate that RBP2, a newly identified histone demethylase, can be induced by CagA via PI3K/AKT-Sp1 pathway depending on AKT phosphorylation. Sp1 directly binds to RBP2 promoter and enhances its expression then the upregulated RBP2 significantly increases Cyclin D1 transcription, which contributes to gastric epithelial cell malignant transformation. Further data indicate that knockdown of endogenous RBP2 dominantly inhibits gastric cancer (GC) development both in vitro and in vivo. In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a novel mechanism for gastric epithelial cell malignant transformation and then gastric cancer (GC). Therefore, RBP2 may link chronic inflammation to tumor development and its inhibition may have potential therapeutic advantages.
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